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Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic. Neutralizing antibody (NAb) assays are used to characterize a positive anti-drug antibody (ADA) response. Harmonization of reporting of NAb assay performance and results enables efficient communication and expedient review by industry and health authorities. Herein, a cross-industry...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The results of an experimental study on the oxidation behavior of loaded gasoline particulate filters (GPFs) from a gasoline direct injection (GDI) engine are reported. PM was loaded on uncatalyzed cordierite GPF mini-cores by exposure to exhaust from a light-duty GDI engine operating during a rich acceleration condition on four fuels: 100% gasoline (E0); a 30% blend of ethanol in gasoline (E30); a 24% blend of isobutanol in g...
Oviposition site selectivity of some New Zealand aquatic macroinvertebrate taxa and implications for stream restorationNARA Subscribed
In many stream restoration projects, macroinvertebrates characteristic of natural conditions do not return despite habitat improvements. One contributing factor may be lack of oviposition sites for some taxa. To understand oviposition requirements of five taxa, we investigated their egg mass distributions on rocks in streams in the Waikato region, New Zealand. We compared insect taxa with aerial adults (caddisfly families Hydr...