J. Storr results 11
· Newest (Page 1/1, per page 25)
Author: J. Storr ×Clear All Filters
Search Results
DHX37 protein and mRNA expression patterns in breast and ovarian cancer and their prognostic implicationsNARA Subscribed
DEAH-box RNA helicase 37 (DHX37) is a highly conserved RNA helicase involved in ribosome biogenesis, RNA metabolism and immune regulation. Dysregulation of RNA helicases has been implicated in tumourigenesis; however, the clinical significance of DHX37 expression in tumours is still emerging and requires further study. This study investigated the expression of DHX37 in large breast and ovarian cancer patient cohorts using immu...
Cytotoxic and Radiosensitising Effects of a Novel Thioredoxin Reductase Inhibitor in Brain CancersNARA Subscribed
The thioredoxin (Trx) system, a key antioxidant pathway, represents an attractive target for cancer therapy. This study investigated the chemotherapeutic and radiosensitising effects of a novel Trx reductase (TrxR) inhibitor, IQ10, on brain cancer cells and the underlying mechanisms of action. Five brain cancer cell lines and a normal cell type were used. TrxR activity and expression were assessed by insulin reduction assay an...
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and MedulloblastomasNARA Subscribed
The thioredoxin (Trx) system is an important enzyme family that regulates cellular redox homeostasis. Protein expression of Trx system family members has been assessed in various cancers and linked to various clinicopathological variables, disease progression, treatment response and survival outcomes but information is lacking in brain tumours. Expression of the system was therefore examined, by immunohistochemistry in differe...
Previous1Next