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The Kulanaokuaiki Tephra Unit 3 (900 C.E.) was a subplinian basaltic scoria eruption, the largest known to have occurred at Kīlauea’s summit. The initiation mechanism and cause(s) of this highly hazardous eruption remain poorly understood, particularly as this style of activity has not been observed in the modern period. We use olivine diffusion timescales from Fe-Mg and lithium zoning to assess magma storage timescales and ev...
Organic matter respiration stoichiometry in the Arctic Ocean is linked to shifts in plankton community compositionNARA Subscribed
The global rate of ocean deoxygenation may be influenced by the molar ratio of dissolved oxygen to organic carbon consumed during microbial respiration. However, respiration stoichiometry and its environmental controls are not fully understood due to sparse direct measurements and limited global coverage. Here, we measured surface concentrations of particulate chemical oxygen demand, particulate organic carbon, and particulate...
Connectivity is a multifaceted concept that has important implications for the management and conservation of marine and freshwater fishes. We developed a conceptual framework that encompasses multiple, interrelated categories of connectedness, including landscape (e.g., structural, functional) connectivity and ecological (e.g., trophic, genetic, demographic) connectivity, that together shape the flow of organisms, energy and...
With over 40 years of history, the multi-jurisdictional effort to restore the health of the Chesapeake Bay ecosystem has yielded some positive outcomes with water quality and natural resources showing measurable signs of improvement. The lessons learned from this multi-year, multi-jurisdictional restoration effort can provide understanding and guidance for ecosystem restoration efforts elsewhere. The 10 “lessons learned” from...
Evaluating the Immunogenicity Risk of Protein Therapeutics by Augmenting T Cell Epitope Prediction with Clinical FactorsNARA Subscribed
Protein-based therapeutics may elicit undesired immune responses in a subset of patients, leading to the production of anti-drug antibodies (ADA). In some cases, ADAs have been reported to affect the pharmacokinetics, efficacy and/or safety of the drug. Accurate prediction of the ADA response can help drug developers identify the immunogenicity risk of the drug candidates, thereby allowing them to make the necessary modificati...