The sheep lung has long been used to model aspects of the human lung, both its normal development and pathological changes that occur in ovine models of lung disease. The similarities between the two species provide an opportunity to investigate phases of lung development that are not accessible for investigation in humans, for example later in gestation. Here we use single cell (sc) RNA-seq to investigate the developmental dy...

Eurasian otters Lutra lutra are protected in Europe and vulnerable due to low reproductive rates. The ability to age cubs may be important to identify and protect breeding places and target seasonal surveys, yet little data exists. We developed a novel method to measure cubs relative to their mother using on-screen pixels on camera trap footage. We tested this on domestic ferrets Mustela furo of known length, then applied it t...

The fast‐slow continuum is a key axis of variation in life history strategies capturing the evolutionary trade‐off between allocation in lifespan versus reproduction. It has been suggested that social behaviour, and therefore network structure, may vary across this continuum, but formal theory remains scarce. We develop a mathematical model to examine how the rate of demographic replacement may influence emergent social networ...

Constructed value of information (CVoI) is an expert elicitation decision‐analytic tool used to prioritize sources of uncertainty based on their potential to improve decision outcomes if resolved. Despite increased application of CVoI, the robustness of CVoI prioritization of sources of uncertainty relative to differences in expert elicitation and scoring methods has not been evaluated. We engaged a group of species experts in...

Staphylococcus aureus bloodstream infections are a significant risk for hemodialysis patients, who would significantly benefit from a preventative vaccine. To-date S. aureus vaccine trials have failed, in part due to lack of consideration of pre-existing immune imprints in relevant patient cohorts. Using a machine learning algorithm this study revealed, prior S. aureus exposure in a cohort of 180 hemodialysis patients, was ass...

Marine isotope substage 11c (~426–366 ka) is widely regarded as the most recent Pleistocene interglacial that is broadly analogous to the Holocene. The timing and magnitude of sea‐level changes during MIS 11 have been much debated, particularly concerning whether sea levels were significantly higher than during the Holocene. Empirical evidence derived from terrestrial (onshore) records in northern Europe that might contribute...