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Mechanical Stretch Disrupts Calcium Dynamics and Redistributes Piezo1 in Human AstrocytesNARA Subscribed
Purpose Astrocytes regulate the activity of nearby neurons so disruption of astrocyte calcium dynamics by traumatic brain injury (TBI) could have profound consequences for neural network activity in the brain. This study aimed to define how mechanical stretch injury alters calcium signaling, mitochondrial membrane potential, and mechanosensitive ion channel organization in human induced pluripotent stem cell (hiPSC)-derived as...
Neonicotinoids (NEOs) are the most widely used class of insecticides worldwide. Consequently, human exposure occurs through multiple pathways, including dietary intake and environmental contact. Previous analytical methods have primarily focused on parent compounds, often excluding key metabolites due to matrix effects and poor quantification in complex biological samples. This gap severely limits the ability to accurately ass...
Global warming intensifies regional precipitation imbalances that disrupt cropland nitrogen cycling and threaten food security. Here, we show that global croplands respond asymmetrically to future precipitation change. Under a middle of the road scenario for 2050, 78% of croplands are projected to become wetter, increasing yields by 15% but raising nitrogen losses by 45%. The remaining 22% that become drier would experience a...
Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIVNARA Subscribed
Glycation is a class of modifications arising from non-enzymatic reactions of reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to many age-related comorbidities. In response to HIV-1 infection, activated T-cells and macrophages shift their predominate metabolism from oxidative phosphorylation to glycolysis. Increased glycolytic flux enhances AGE formation, wh...
Emergent coral reef patterning via spatial self-organizationNARA Subscribed