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Vaccine strategies for cancer prevention in Lynch syndrome: the potential of dendritic cell-based therapyNARA Subscribed
Cancer vaccines offer a promising strategy for cancer prevention, particularly in hereditary cancer syndromes such as Lynch syndrome (LS). LS is characterized by a high lifetime risk of developing various malignancies due to defects in DNA mismatch repair, leading to an accumulation of mutations, particularly frameshift insertion/deletions (indels) within microsatellite loci. These indels create shared tumour-specific neoantig...
Nature-based solutions (NBSs) offer an opportunity to address environmental and societal challenges worldwide while simultaneously providing benefits for human well-being as well as biodiversity. Despite a growing demand and evidence base for NBSs in coastal systems, the scaling of their implementation and mainstreaming of their principles in policy and practice are constrained by multiple barriers, such as misinterpretations...
Float, fly, then sink: wetland plant seed buoyancy is lost after internal dispersal by waterbirdsNARA Subscribed
Seed dispersal distance is an important indicator of how well a plant species can cope with environmental changes. Seeds of wetland plants are primarily dispersed by hydrochory (floating on the water surface) or endozoochory (ingestion and egestion by animals). However, both mechanisms can also be combined (diplochory), which increases dispersal distances. In wetlands, seeds often float on the water surface before ingestion an...
Chung-Jansen syndrome is a neurodevelopmental disorder characterized by intellectual disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic variants in the PHIP gene that encodes for the Pleckstrin homology domain-interacting protein, which is part of an epigenetic modifier protein complex. Therefore, we hypothesized that PHIP haploinsufficiency may impact genome-wide DNA methylation (DNAm...
The added value of simulated near-surface wind speed over the Alps from a km-scale multimodel ensembleNARA Subscribed
The advancement of computational resources has allowed researchers to run convection-permitting regional climate model (CPRCM) simulations. A pioneering effort promoting a multimodel ensemble of such simulations is the CORDEX Flagship Pilot Studies (FPS) on “Convective Phenomena over Europe and the Mediterranean” over an extended Alps region. In this study, the Distribution Added Value metric is used to determine the improveme...
Investigating the representation of heatwaves from an ensemble of km-scale regional climate simulations within CORDEX-FPS convectionNARA Subscribed
Heatwaves (HWs) are high-impact phenomena stressing both societies and ecosystems. Their intensity and frequency are expected to increase in a warmer climate over many regions of the world. While these impacts can be wide-ranging, they are potentially influenced by local to regional features such as topography, land cover, and urbanization. Here, we leverage recent advances in the very high-resolution modelling required to elu...
The increase in computational resources has enabled the emergence of multi-model ensembles of convection-permitting regional climate model (CPRCM) simulations at very high horizontal resolutions. An example is the CORDEX Flagship Pilot Study on “Convective phenomena at high resolution over Europe and the Mediterranean”, a set of kilometre-scale simulations over an extended Alpine domain. This first-of-its-kind multi-model ense...
To charge or not to charge? Using Prospect Theory to model the tradeoffs of electric vehicle usersNARA Subscribed
Electric vehicle (EV) users who aim to become flexibility providers face a tradeoff between staying in control of charging and minimizing their electricity costs. The common practice is to charge immediately after plugging in and use more electricity than necessary. Changing this can increase the EV’s flexibility potential and reduce electricity costs. Our extended electricity cost optimization model systematically examines ho...
Rapid identification of the rise and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern remains critical for monitoring of the efficacy of diagnostics, therapeutics, vaccines, and control strategies. A wide range of SARS-CoV-2 next-generation sequencing (NGS) methods have been developed over the last years, but cross-sequence technology benchmarking studies have been scarce. In the curre...
How the timing of visual feedback influences goal-directed arm movements: delays and presentation ratesNARA Subscribed
Visual feedback normally helps guide movements to their goal. When moving one’s hand, such guidance has to deal with a sensorimotor delay of about 100 ms. When moving a cursor, it also has to deal with a delay of tens of milliseconds that arises between the hand moving the mouse and the cursor moving on the screen. Moreover, the cursor is presented at a certain rate, so only positions corresponding with the position of the mou...
The Summer School Oncology Groningen: Improving a Successful International Course by Refining the Old, Maintaining What’s GoodNARA Subscribed
For more than two decades, the International Summer School Oncology for Medical Students (ISOMS) has organized a biennial 2-week international summer school program in Groningen, the Netherlands. The summer school aims to increase knowledge about general cancer care, reduce fear of talking to cancer patients, and expose students to cancer-related problems. After 22 years, there was a need to improve the summer school format, t...
Development of a dedicated 3D printed myocardial perfusion phantom: proof-of-concept in dynamic SPECTNARA Subscribed
We aim to facilitate phantom-based (ground truth) evaluation of dynamic, quantitative myocardial perfusion imaging (MPI) applications. Current MPI phantoms are static representations or lack clinical hard- and software evaluation capabilities. This proof-of-concept study demonstrates the design, realisation and testing of a dedicated cardiac flow phantom. The 3D printed phantom mimics flow through a left ventricular cavity (LV...
Impact of resolution on the atmosphere–ocean coupling along the Gulf Stream in global high resolution modelsNARA Subscribed
We have investigated the horizontal resolution dependence of the ocean–atmosphere coupling along the Gulf Stream, of simulations made by six Global Climate Models according to the HighResMIP protocol, and compared it with reanalysis and remote sensing observations. Two ocean–atmosphere interaction mechanisms are explored in detail: The Vertical Mixing Mechanism (VMM) associated with the intensification of downward momentum tra...