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Periodical cicada ( Magicicada spp.) ranges have continued to decline even as their habitat has rebounded from historic lows. This counterintuitive trajectory may be a consequence of Magicicada 's limited dispersal capabilities combined with their requirement that individual host trees survive across decades. Indeed, we find that the presence of Magicicada breeding populations is best predicted by tree cover in 1930, not by pr...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Ten questions concerning indoor dustNARA Subscribed
Global Patterns and Drivers of Seagrass Biomass, Net Primary Production and Meadow StructureNARA Subscribed
Aim We decipher global patterns in seagrass growth and structure to advance seagrass science, facilitate multidisciplinary research, and promote effective management strategies and policy development for seagrass habitats. Location: Global. Time period: 1975 to 2024. Major taxa studied: Seagrasses—marine angiosperms. Methods A global data set on seagrass total biomass, total net primary productivity (NPP), shoot density, and p...
The essential role of large research vessels in marine ecosystem observations and ocean sustainabilityNARA Subscribed
Our understanding of marine ecosystems and ability to manage them sustainably has come from multidisciplinary observations made repeatedly over long periods of time. These long‐term ecosystem observations depend on the capabilities of large research vessels, which play an essential role in the collection of global ocean observations. Research vessels serve as large, stable platforms for collecting high volume samples from the...
Bioanalytical Method Comparison Strategy for Clinical Anti-drug Antibody ImmunoassaysNARA Subscribed
Per FDA guidance, method comparability should be established if an anti-drug antibody (ADA) assay is run by two or more independent laboratories during a study. Genentech, Inc. is evaluating an immunogenicity risk-based comparability approach consisting of both technical and clinical aspects. Technical comparability of the relative sensitivity (RS) is assessed using the Two One-Sided T-tests (TOST) statistical analysis which e...
Purpose of Review Environmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early environmental exposures have been limited in size and diversity, hindering power and generalizability. With harmonized data from over 60,000 participants representing 69 pregnancy cohorts, the National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) P...