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Comparing phosphatised galleried stereom of Ordovician Cincinnaticrinus to modern Endoxocrinus illustrates preservation by micromoldingNARA Subscribed
Fossil echinoderm ossicles are often occluded by syntaxial overgrowths which obscure stereom. Phosphatized ossicles from insoluble residues show fine microstructure. We investigated phosphatized stereom in Cincinnaticrinus columnals in insoluble residues from the Ordovician around Cincinnati, Ohio USA. Microstructures appeared to be stereom micromolds. We tested this hypothesis by examining residue and thin sections of undisso...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Genome-wide association study (GWAS) identifies genetic loci controlling Distinctness, Uniformity, and Stability (DUS) traits in wheatNARA Subscribed
Key message Genetic analysis of wheat Distinctness, Uniformity, and Stability (DUS) characteristics identifies significant marker–trait associations for 15 DUS traits, including associations for ‘seed: colouration with phenol’ closely linked to Ppo-A1 . Crop improvement via breeding underpins the yield gains required for future food security. Commercial development of new varieties is supported by the legal protection afforded...
This study investigates the age-based life-history traits of two groundfish species, the spotted moray eel ( Gymnothorax moringa ) and squirrelfish ( Holocentrus adscensionis ), found in Ascension Island and St Helena. Both islands are part of the UK Overseas Territories (UKOTs) and are known for their fish biodiversity. The research aims to provide essential life-history information to support sustainable management of these...
Scope for growth is optimized across a limited temperature range in an imperiled freshwater musselNARA Subscribed
Predicting effects of rising temperatures on the health and physiology of aquatic organisms is receiving increasing attention, particularly in arid regions with limited freshwater habitat. One approach to estimating energetic health of aquatic ectotherms is scope for growth (SFG)—the net energy available for reproduction and growth after meeting basic maintenance costs. We examined the relationships between temperature, cleara...
We assembled a European bread wheat ( Triticum aestivum L.) association mapping panel ( n = 480) genotyped using a 90,000 feature single nucleotide polymorphism array, with the aim of identifying genetic loci controlling resistance to four fungal diseases: yellow (stripe) rust (YR), brown (leaf) rust (BR), Septoria tritici blotch (ST) and powdery mildew (PM). Simulations showed our panel to have good power to detect genetic lo...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Fine-scale residency and temperature-driven habitat selection in a migratory shark speciesNARA Subscribed
Many marine species exhibit complex and diverse movements that vary across spatial and temporal scales. These movements must be accounted for when designing effective management and conservation efforts. While environmental cues such as temperature and salinity have been shown to influence the movements of mobile species, it is increasingly documented that social factors can also influence space use and population behaviour. U...
Identifying illegal fishing activities from Automatic Identification System (AIS) data is difficult since AIS messages are broadcast cooperatively, the ship’s master controls the timing, and the content of the transmission and the activities of interest usually occur far away from the shore. This paper presents our work to predict ship types using AIS data from satellites: in such data, there is a pronounced imbalance between...
Site‐Specific Nutrient Data Reveal the Importance of Soils in Driving the Mycorrhizal Make‐Up of Woody Vegetation WorldwideNARA Subscribed
Aim Arbuscular mycorrhizas (AM) and ectomycorrhizas (ECM) have different impacts on nutrient cycling, carbon storage, community dynamics and enhancement of photosynthesis by rising CO 2 . Recent global analyses have concluded that patterns of AM/ECM dominance in forests worldwide are shaped by climate, with soil nutrients contributing negligible additional explanatory power. However, their reliance on nutrient data from GIS su...
Flowering time synchronizes reproductive development with favorable environmental conditions to optimize yield. Improved understanding of the genetic control of flowering will help optimize varietal adaptation to future agricultural systems under climate change. Here, we investigate the genetic basis of flowering time in winter wheat ( Triticum aestivum L.) using an eight-founder multi-parent advanced generation intercross (MA...