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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Key message Soybean rust-associated haplotypes around significant SNPs show variable effects across diverse accessions, while distinct soybean mosaic virus-resistant haplotypes were identified at the Rsv1 locus on chromosome 13. Abstract Soybean rust (SBR), caused by the fungal pathogen Phakopsora pachyrhizi, significantly affects soybean yield and quality globally. Here, we present an association and haplotype analysis of 2,8...
Endoluminal Catheter Pulsed Field Ablation for the Treatment of Atherosclerotic Vascular DiseaseNARA Subscribed
Purpose Atherosclerotic vascular disease remains a leading cause of morbidity and mortality worldwide. Current treatments such as angioplasty, stenting, and atherectomy are invasive and limited by restenosis, thrombosis, and incomplete long-term efficacy. Pulsed field ablation (PFA), a nonthermal electroporation-based modality, has demonstrated safety in other cardiovascular applications, but it has not been applied for the tr...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Forest conversion for agriculture is a major cause of tropical biodiversity loss, but its impacts vary with spatial scale. Higher species turnover in forests than in farmland means that land‐use change causes greater biodiversity loss at broader than at local scales, yet broad‐scale assessments are scarce. Phylogenetic diversity is increasingly prioritised in conservation to protect evolutionary history under global change, ye...
Measured thoracic gas volume using the bod pod air displacement plethysmography system versus three predictionsNARA Subscribed
Purpose Bod Pod air displacement plethysmography is a common method to estimate body fat percentage (%BF). To determine body volume from this method, thoracic gas volume (TGV) must be quantified. Measured TGV was compared to three predictions: the default prediction formula in the Bod Pod software from Crapo (CRAPO), a relatively new prediction that relies on height and body mass as the predictors from Ducharme (DUCHARME), and...
Can Solar‐Powered Irrigation Systems Naturally Meet Crop Water Requirements? Proof of Concept From a Case Study in Sub‐Saharan AfricaNARA Subscribed
Irrigation scheduling is crucial for ensuring precise water delivery to crops. However, in many sub‐Saharan African irrigation schemes, water is applied without considering crop water needs, resulting in low crop water productivity and low yields. Solar‐powered irrigation systems can automatically meet these needs by utilizing solar radiation, which drives both evapotranspiration and solar panel power production for pumping. T...
Effects of Interphase and Interpulse Delays on Tissue Impedance and Pulsed Field AblationNARA Subscribed
Purpose High-frequency irreversible electroporation (H-FIRE) is a pulsed field ablation (PFA) technique that employs a series of high-voltage, microseconds-long positive and negative pulses, separated by interphase (d1) and interpulse (d2) delays to non-thermally ablate tissue. Previous experimental and computational data suggest an impact of delays on nerve excitation and electrochemical effects. However, the impact of delays...
Transient Lymphatic Remodeling Follows Sub-Ablative High-Frequency Irreversible Electroporation Therapy in a 4T1 Murine ModelNARA Subscribed
High-frequency irreversible electroporation (H-FIRE) is a minimally invasive local ablation therapy known to activate the adaptive immune system and reprogram the tumor microenvironment. Its predecessor, irreversible electroporation (IRE), transiently increases microvascular density and immune cell infiltration within the surviving non-ablated and non-necrotic tumor region, also known as the viable tumor region. However, the i...
Tropical Land‐Use Change Disrupts Zeta‐Diversity Across TaxaNARA Subscribed
Land‐use change causes community turnover via local extinction and colonisation of species, driving biotic homogenization or heterogenization at larger spatial scales. Quantification of these processes has focused on beta‐diversity metrics, which upweight rarity and overlook the role of widespread species. A key knowledge gap is understanding the impact of land‐use change on both rare and widespread species—zeta‐diversity—allo...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...