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Springer Nature4
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Journal of Pharmacokinetics and Pharmacodynamics2
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Jacob Leander results 4 · Newest (Page 1/1, per page 25)
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A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseasesNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2021 · Vol. 48 · Issue 4 · Springer
Jacob Leander; Mikael Sunnåker; Dinko Rekić; Sergey Aksenov; Ulf G. Eriksson; Susanne Johansson; Joanna Parkinson
Verinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of uric acid, which can lead to acute kidney injury. The combination is currently in development for chronic kidney disease and heart failure. The aim o...
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Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic DynamicsNARA Subscribed
The AAPS Journal · 2018 · Vol. 20 · Issue 5 · Springer
Helga Kristin Olafsdottir; Jacob Leander; Joachim Almquist; Mats Jirstrand
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Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihoodNARA Subscribed
Journal of Pharmacokinetics and Pharmacodynamics · 2015 · Vol. 42 · Issue 3 · Springer
Joachim Almquist; Jacob Leander; Mats Jirstrand
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Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker RatsNARA Subscribed
The AAPS Journal · 2015 · Vol. 17 · Issue 3 · Springer
Jacob Leander; Joachim Almquist; Christine Ahlström; Johan Gabrielsson; Mats Jirstrand
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