mRNA vaccine formulations are generally considered to pose a lower genotoxic risk than conventional small-molecule pharmaceuticals; however, long-term data regarding their potential genotoxicity remain limited. Furthermore, to date, no standardized genotoxicity testing guidelines specifically tailored to the unique characteristics of mRNA vaccines have been formally established. In this study, we conducted a comprehensive geno...

The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitating further investigation to ensure their safety. To address this issue, we aimed to evaluate the toxicological effects of SARS-CoV-2 mRNA vaccine candidates formulated with four different types of lipid nanoparticles in ICR mice, focusing on repeated doses and administration routes. We conducted an extensi...

Less than 1% of Staphylinidae are known to be confined to coastal habitats. To explore the origins of coastal colonization within the tribe Athetini Casey, we present a revised molecular phylogeny. The dataset comprised partial mitochondrial COI , COII , 16S rDNA, NADH1 , partial nuclear 18S rDNA and 28S rDNA. We chose a total of 95 species in 51 genera, including 14 coastal species in eight genera and 21 outgroup species from...