Amnestic mild cognitive impairment represents a prodromal stage of Alzheimer’s disease characterized by episodic memory deficits and subtle alterations in brain function. Although the traditional herbal formula Kami Guibi-tang (KGT) has been reported to exert cognitive benefits, its neural effects have not been evaluated using functional neuroimaging. In this randomized, double-blind, placebo-controlled trial, 84 individuals w...

Immunodeficient mouse models are invaluable tools for preclinical research, particularly for cancer therapies and studies of the human immune system. Notably, strains with combined Prkdc (scid) and Il2rg (null) mutations—such as NOG and NSG mice— are widely used due to their profound immunodeficiency, allowing efficient engraftment of various human cells. However, these models were generated by disrupting the Il2rg gene throug...

Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is the standard surgical treatment for familial adenomatous polyposis (FAP) in our institution. Stapled and hand-sewn IPAA differ in the amount of retained rectal mucosa, influencing both adenoma risk and functional outcomes. In this retrospective cohort study, we compared oncological and functional outcomes between the two techniques. Consecutive patie...