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Background As the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) continues to rise, drug development has accelerated, with growing interest in therapeutic strategies that harness metabolic hormones. Metabolic hormone-based approaches, particularly those originally developed for obesity and diabetes, have shown potential to mitigate MASH. Notably, the glucagon-like peptide-1 receptor (GLP-1R) agonist sema...
Diuron, an additive biocide in antifouling paints, is widely employed to curtail the attachment of organisms on submerged surfaces in aquatic structures. Despite the detection of diuron in aquatic ecosystems, information regarding its acute and chronic impacts on aquatic invertebrates, particularly planktonic crustaceans, remains limited. In this study, we analyzed the acute (24 h) and chronic (12 days exposure across three ge...
Incorporating ecology into gene drive modellingNARA Subscribed
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into wild populations, represents a promising new tool in the fight against vector‐borne diseases, agricultural pests and invasive species. Due to the risks involved, gene drives have so far only been tested in laboratory settings while their population‐level behaviour is mainly studied using mathematical and computational models. The spread...