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The myofibrillar myopathy–linked variant DES-p.T341P impairs desmin filament assemblyNARA Subscribed
Background Desminopathies are clinical heterogenous and range from isolated skeletal myopathies to different cardiomyopathies or combinations of both. At the molecular level, an aberrant cytoplasmic desmin aggregation is a typical hallmark of pathogenic DES variants. Currently, it is difficult to predict an aberrant desmin aggregation of novel DES variants without functional analysis. Methods Therefore, we investigate in this...
The safety of using ethanol-based products for hygienic hand disinfection in healthcare workers is controlled by restricting air levels. This raises the question of whether these workers are sufficiently protected against potential dermal absorption. The study aim was to determine the contribution of the dermal route to the total uptake of ethanol. A laboratory-controlled study of 25 sequential alcohol-based-hand-rubs (ABHRs)...
Perfluorooctanesulfonic acid (PFOS) is an environmental contaminant with a long half-life in animals. Risk assessment of PFOS in livestock and food tissue can be conducted with physiologically-based kinetic (PBK) models. For fast-growing livestock, changes in body weight affect the kinetics of PFOS primarily through tissue dilution, which needs to be considered when using a PBK model. A generic PBK model was used to predict ti...
Algal glycans promote microbial turnover of organic matter through stabilization of subtidal permeable sandy sedimentsNARA Subscribed
Permeable sands on continental shelves host microbial communities that drive organic carbon turnover, oxygen fluxes and nitrogen loss. Advective porewater flow associated with sedimentary bedforms maintains these rates and fluxes. Modeling and laboratory studies suggest that advective porewater flow is tightly coupled to bedform stability. However, the impacts of in situ bedform stability on biogeochemical fluxes in subtidal s...
Native Cape Fynbos legumes in South Africa do not nodulate with rhizobium strains associated with invasive Australian Acacia speciesNARA Subscribed
Mutualisms with nitrogen-fixing rhizobia have been linked to the invasion success of alien legumes, especially in areas with nutrient poor soils. While generalist alien legumes can potentially form symbioses with a range of resident rhizobia, specialist alien legumes may fail to find compatible symbionts in their new ranges. In some instances, alien legumes have been co-introduced with their co-evolved rhizobia. These co-invad...
The interactions between clouds and aerosols represent one of the largest uncertainties in assessing the Earth’s radiation budget, highlighting the importance of research on the transition zone (TZ) within the cloud-aerosol continuum. This study assesses the global distribution of TZ conditions, analyzes its optical characteristics, and determines the cloud or aerosol types most commonly associated with them, using the cloud-a...
The development of offshore wind farms (OWFs) in the North Sea is a crucial component for the transition to renewable energy. However, local hydrodynamics in the vicinity of OWF turbine foundations may be affected due to their interaction with tidal currents. This study investigates the impact of offshore wind turbine foundations on local hydrodynamics and stratification in the southern North Sea. We conducted a series of meas...
The Seaward Migration of European Eel at a Continental Scale: A Europe‐Wide Biotelemetry Meta‐AnalysisNARA Subscribed
The European eel ( Anguilla anguilla L.) has a catadromous life cycle, with a single panmictic population that colonises continental Europe and northern Africa yet migrates 5000 to 9000 km to spawn in the Atlantic Ocean. It is unknown how this continental migration is organised so individual eels arrive in time for spawning with conspecifics. This meta‐analysis combined tracking data from 18 water bodies in freshwater and tran...