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Springer Nature1
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Immunologic Research1
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20251
Jan Jacob Schuringa results 1 · Newest (Page 1/1, per page 25)
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High expression of signal regulatory protein beta 2 marks a favourable prognostic AML subgroup and associates with increased sensitivity to phagocytosisNARA Subscribed
Immunologic Research · 2025 · Vol. 73 · Issue 1 · Springer
Nienke Visser; Nisha K. van der Meer; Yuan He; Gerwin Huls; Jan Jacob Schuringa; Edwin Bremer
Acute myeloid leukaemia is an aggressive hematologic malignancy that remains exceedingly difficult to treat despite recent advancements. High expression of CD47 on leukemic blasts interacts with the inhibitory receptor SIRP-alpha (SIRP-α) on innate immune cells, resulting in a strong "don't eat me" signal. Therefore, identifying AML patients who could benefit from immune-targeted therapies is crucial SIRP-β2 is predominantly e...
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