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Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapyNARA Subscribed
Heart failure (HF) affects over 64 million people worldwide causally linked to fibrotic scarring. None of the available cardiac drugs target fibrosis directly, underlining unmet clinical need for novel therapies. This study aimed to explore the therapeutic potential of the cysteine protease inhibitor aloxistatin as a repurposed drug candidate to combat fibrotic progression in predictive HF models. Aloxistatin reduced migratory...
First report of the root-lesion nematode Pratylenchus thornei infecting bread wheat (Triticum aestivum) in EthiopiaNARA Subscribed
The root-lesion nematode Pratylenchus thornei Sher & Allen, 1953 is one of the major constraints limiting wheat production and productivity in many wheat-growing regions worldwide. However, information on its occurrence and pathogenicity in Ethiopia remains limited. In this study, root-lesion nematodes extracted from soil and infected root samples collected from wheat fields in the East and West Arsi zones were identified as P...
Egg and larval production of Eastern Baltic cod in captivity over one spawning seasonNARA Subscribed
Eastern Baltic cod ( Gadus morhua ) has experienced a dramatic decline in biomass, distribution, size and condition over recent decades, related to a combination of fishing pressure and environmental stressors. Reduced parental size and condition are known to impact reproductive success, affecting egg quality, fertilization and hatching success and larval survival. However, how these reproductive traits vary throughout the spa...
Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoningNARA Subscribed
Sustained effort has been dedicated to the development of novel cholinesterase reactivators—the only causal antidotes—to counter organophosphorus (OP) intoxication. As more lethal nerve agents—such as A-agents—continue to emerge, the existing arsenal of causal antidotes remains unchanged. Approved oxime reactivators— 2-PAM , HI-6 , and LüH-6 —are restricted by their limited efficacy spectrum, poor blood–brain barrier permeabil...
Geographic Variation in the Diet of Red Knot ( Calidris canutus ) Chicks Reflects Local Prey CommunitiesNARA Subscribed
Aim To describe and compare the diets of an Arctic‐breeding shorebird, the Red Knot ( Calidris canutus ), across three geographically distinct breeding sites. We aimed to document the dietary patterns and identify key prey groups that characterise each population's foraging ecology. Location Northwest Alaska (Nome), Northeast Greenland (Zackenberg) and North‐Central Russia (Taimyr Peninsula). Taxon Red Knot (Aves: Calidris can...
To advance understanding of meiofauna, key components of marine benthic ecosystems, an international team conducted a morphology-based taxonomic survey and workshop around São Miguel, the largest Azorean island, in 2019. The survey yielded critical baseline data on meiofaunal diversity and, despite taxonomic challenges that limited identification of certain taxa, laid a solid foundation for further research. To expand these fi...
Plankton communities today and tomorrow—potential impacts of multiple global change drivers and marine heatwavesNARA Subscribed
In the context of global change, marine organisms are subjected not only to gradual changes in abiotic parameters, but also to an increasing number of extreme events, such as heatwaves. However, we still know little about the influence of heatwaves on the structure of marine communities, and experimental studies are needed to test the impact of heatwaves alone and in combination with other environmental drivers. Here, we condu...
Limited efficiency of wet scrubbers in reducing the environmental impact of ship-emitted particlesNARA Subscribed
Sulfur dioxide pollution by ship emissions can be efficiently decreased by using exhaust gas scrubbers, yet particles can pass through the scrubber and be released into the atmosphere. Here, we studied the impact of using a wet scrubber on the composition of particle emissions, by single-particle analysis. At low engine loads, results show no significant changes in particle composition of metals, salts, and polycyclic aromatic...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Fatal dengue virus infection in an unvaccinated travelerNARA Subscribed
Dengue is an increasing threat to individuals living in or visiting endemic countries. Effective vaccines have become available, but their use in travelers is typically only recommended to individuals with documented prior infection. We present a fatal case of severe dengue in an unvaccinated traveler without known prior dengue virus infection but longitudinal serologic and molecular evidence for secondary infection. In the co...
Global Marine Flyways Identified for Long‐Distance Migrating Seabirds From Tracking DataNARA Subscribed
Aim To identify the broad‐scale oceanic migration routes (‘marine flyways’) used by multiple pelagic, long‐distance migratory seabirds based on a global compilation of tracking data. Location Global. Time Period 1989–2023. Major Taxa Studied Seabirds (Families: Phaethontidae, Hydrobatidae, Diomedeidae, Procellariidae, Laridae and Stercorariidae). Methods We collated a comprehensive global tracking dataset that included the mig...
Seismological monitoring of magmatic and tectonic earthquakes in the East Eifel Volcanic Field, GermanyNARA Subscribed
In 2013 there were reports on exceptionally deep earthquakes in ca. 40 km depth below the intraplate East Eifel Volcanic Field, Germany. Due to this observation the regional seismological monitoring network was improved to better explore this unusual seismicity. In order to acquire the necessary instruments, financial resources, and man power, a close partnership was initiated between the local state seismological service and...
No general support for functional diversity enhancing resilience across terrestrial plant communitiesNARA Subscribed
Aim Understanding the mechanisms promoting resilience in plant communities is crucial in times of increasing disturbance and global environmental change. Here, we present the first meta‐analysis evaluating the relationship between functional diversity and resilience of plant communities. Specifically, we tested whether the resilience of plant communities is positively correlated with interspecific trait variation (following th...