Anthropogenic pressures drive landscape transformation and climate change, which threaten habitat suitability and often perpetuates biodiversity loss. Wide-ranging behaviour in large carnivores typically conflicts with human activities driving population declines. Cheetah are particularly vulnerable, with the smallest remaining global population occupying only 9% of their historical range. This study aimed to define and deline...

Anthropogenic disturbance of wildlife is increasing globally. Generalizing impacts of disturbance to novel situations is challenging, as the tolerance of animals to human activities varies with disturbance frequency (e.g. due to habituation). Few studies have quantified frequency‐dependent tolerance, let alone determined how it affects predictions of disturbance impacts when these are extrapolated over large areas. In a compar...

Large grazers (megaherbivores) have a profound impact on ecosystem functioning. However, how ecosystem multifunctionality is affected by changes in megaherbivore populations remains poorly understood. Understanding the total impact on ecosystem multifunctionality requires an integrative ecosystem approach, which is especially challenging to obtain in marine systems. We assessed the effects of experimentally simulated grazing i...

In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS) glycosaminoglycans are deemed essential to the glomerular filtration barrier, including the glomerular endothelial glycocalyx. Animal studies have shown that loss of HS results i...

Working memory and episodic memory are two different processes, although the nature of their interrelationship is debated. As these processes are predominantly studied in isolation, it is unclear whether they crucially rely on different neural substrates. To obtain more insight in this, 81 adults with sub-acute ischemic stroke and 29 elderly controls were assessed on a visual working memory task, followed by a surprise subsequ...

Purpose There is an annual incidence of 50,000 glioma cases in Europe. The optimal treatment strategy is highly personalised, depending on tumour type, grade, spatial localization, and the degree of tissue infiltration. In research settings, advanced magnetic resonance imaging (MRI) has shown great promise as a tool to inform personalised treatment decisions. However, the use of advanced MRI in clinical practice remains scarce...

Evaluation of long-term management regimes is important for guiding biodiversity conservation in salt marshes. However, such long-term experiments are sparse. Using a 46-year experiment in a salt marsh, we evaluated long-term effects of eight different management regimes (treatments; control, grazing, mowing, and their combinations) on the expansion of a late successional plant species ( Elytrigia atherica ), plant species ric...