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Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation. In this study, we present an integrated characterisation of the genomic organisation, tissue expression and dietary resp...
Plants That Evolved Under High Phylogenetic Diversity Have Higher Invasion Success, Particularly in Undisturbed CommunitiesNARA Subscribed
The evolutionary imbalance hypothesis predicts that species from ecologically stable regions of high genetic potential and intense competition are more likely to be invasive, while regions with the opposite characteristics are more likely to be invasible. Relative phylogenetic diversity (PD) of species' indigenous ranges could indicate evolutionary imbalance and help identify high‐risk invaders and vulnerable communities. We t...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Hydrogeology, European colonialism, local communities and First Peoples: moving beyond business as usualNARA Subscribed
European colonialism altered the connections between First Peoples, local communities, and groundwater systems across the world. In many countries, the practice of hydrogeology remains intertwined with the economic agendas of colonial settler communities, making colonialism a useful lens through which to consider our work. This paper briefly summarizes connections between First Peoples, local communities and groundwater, as we...
The branching green macroalga Cladophora glomerata and its epiphytic microbiome dominate summer biomass in the Eel River, a Northern California river under Mediterranean (summer drought, winter rain) seasonality. Green Cladophora streamers proliferate in early summer, then change to yellow and then red‐brown as epiphyte loads increase. We characterised successional changes in epiphytic bacteria on Cladophora , examining both c...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
When can we detect lianas from space? Toward a mechanistic understanding of liana‐infested forest opticsNARA Subscribed
Lianas, woody vines acting as structural parasites of trees, have profound effects on the composition and structure of tropical forests, impacting tree growth, mortality, and forest succession. Remote sensing could offer a powerful tool for quantifying the scale of liana infestation, provided the availability of robust detection methods. We analyze the consistency and global geographic specificity of spectral signals—reflectan...
Understanding population connectivity and genetic diversity is of fundamental importance to conservation. However, in globally threatened marine megafauna, challenges remain due to their elusive nature and wide‐ranging distributions. As overexploitation continues to threaten biodiversity across the globe, such knowledge gaps compromise both the suitability and effectiveness of management actions. Here, we use a comparative fra...