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Canada's Forests Are Shifting From a Recovery‐Driven Carbon Sink to a Disturbance‐Driven Carbon SourceNARA Subscribed
Canada's terrestrial ecosystems are critical to the global carbon cycle and are responding to unprecedented climate change and wildfire disturbance. However, our understanding of Canada's historical (~1920—present) carbon cycle is incomplete. There are also no published physically coherent (i.e., those that respect conservation laws) wall‐to‐wall estimates of all major carbon pools and fluxes for Canada. Existing assessments v...
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic. Neutralizing antibody (NAb) assays are used to characterize a positive anti-drug antibody (ADA) response. Harmonization of reporting of NAb assay performance and results enables efficient communication and expedient review by industry and health authorities. Herein, a cross-industry...
Evolving immunogenicity assay performance expectations and a lack of harmonized neutralizing antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. A team of experts within the American Association of Pharmaceutical Scientists’ Therapeutic Product Immunogenicity Community across industry and the Food and Drug Administration address...
The integrated WRF/urban modelling system: development, evaluation, and applications to urban environmental problemsNARA Subscribed
To bridge the gaps between traditional mesoscale modelling and microscale modelling, the National Center for Atmospheric Research, in collaboration with other agencies and research groups, has developed an integrated urban modelling system coupled to the weather research and forecasting (WRF) model as a community tool to address urban environmental issues. The core of this WRF/urban modelling system consists of the following:...
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