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Aim To evaluate the population pharmacokinetics of unbound F-Ara-A (the circulating metabolite of fludarabine) in 211 patients (age range, 0.1–63.4 years) undergoing allogeneic haematopoietic stem cell transplantation conditioning. Methods Total ( n = 2480) and unbound ( n = 1403) F-Ara-A concentrations were measured in blood samples collected at timed intervals after fludarabine doses ranging from 10 to 50 mg/m 2 and infused...
Evolving immunogenicity assay performance expectations and a lack of harmonized neutralizing antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. A team of experts within the American Association of Pharmaceutical Scientists’ Therapeutic Product Immunogenicity Community across industry and the Food and Drug Administration address...
Chemical analysis of calcified structures continues to flourish, as analytical and technological advances enable researchers to tap into trace elements and isotopes taken up in otoliths and other archival tissues at ever greater resolution. Increasingly, these tracers are applied to refine age estimation and interpretation, and to chronicle responses to environmental stressors, linking these to ecological, physiological, and l...
Recent Developments in Additive-Manufactured Intermetallic Compounds for Bio-Implant ApplicationsNARA Subscribed
Purpose This paper reviews the recent developments of two newly developed intermetallic compounds (IMCs) of metallic glasses (MGs) and high-entropy alloys (HEAs) as potential implantable biomaterials. Methods The paper commences by summarizing the fundamental properties of recently developed MGs and high-entropy alloys (HEAs). A systematic review is presented of the recent literature about the use of AM technology in fabricati...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The movement of marine animals feeding at the sea surface is restricted by wave drag and a reduction in propulsive efficiency. Many rorqual whale species lunge feed at the surface, yet existing methodologies for detecting lunges in accelerometer data have not been applied to surface‐feeding behavior. Our study aimed to develop a method to detect surface‐feeding behavior in accelerometer data and in doing so, determine whether...
Invertebrates provide the majority of ecosystem services; thus, it is important that they be inventoried, monitored, and protected. Nevertheless, inventories, monitoring, and management generally focus on vertebrates and flowering plants. Consequently, there are few guidelines or case studies for invertebrates. We present a procedure for developing a monitoring program for species‐rich invertebrates that entails (1) characteri...
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