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Accurate and precise age determination is essential for estimating key life-history parameters in fishes. Recent studies suggest that some fisheries management metrics, such as mortality, may be robust to biased age estimates. Thus, it can be more important to identify the most precise structure for age assignment. However, precision can vary geographically, highlighting the need for location-specific evaluations. Smallmouth b...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
As climate change progresses and severe disturbances become routine, understanding rates and mechanisms of recovery in habitat-forming species is central to predicting the broader response of ecosystems to climate change. Here, we combined acute experimental heat stress and RNA sequencing to explore patterns of transcriptome plasticity and resilience to heat stress in a common Acropora coral from the World Heritage-listed Ning...
Freshwater fish condition responses to hydrological disturbance are species‐ and scale dependentNARA Subscribed
Modification of river flows is a major cause of freshwater fish population declines in many parts of the world. Identifying the precise mechanisms of these declines represents a significant challenge, as a range of stressors can simultaneously impact various components of fish health, fitness and population dynamics. Here we investigate the role of river flows and other biophysical factors on spatio‐temporal variation in fresh...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Evaluation of the Anti-Inflammatory Effects of Novel Fatty Acid-Binding Protein 4 Inhibitors in MicrogliaNARA Subscribed
Fatty acid-binding protein 4 (FABP4) is a key lipid binding protein expressed in microglia, which has been demonstrated to play a critical role in microglial-mediated neuroinflammation, a component of many neurodegenerative diseases. Compounds able to inhibit the function of FABP4 have shown promise in reducing microglial-mediated neuroinflammation, however, their physicochemical properties would prevent their ability to be ea...
Predicting the invasiveness of alpine newts in the UKNARA Subscribed
Predicting invasion risk to novel environments is essential for risk management and conservation decision making but the evolutionary lineage at which to make these predictions is often unclear. Here we predict the current suitability across the United Kingdom (UK) for the alpine newt Ichthyosaura alpestris , a species with a complex evolutionary history, a broad native range, a growing number of introduced populations and ane...
Despite the universal fascination with the tusk of the narwhal, the function of this long, spiraled tooth is still debated, primarily because few people have observed how narwhals ( Monodon monoceros ) use their tusks in the wild. Using an unmanned aerial vehicle (UAV), we recorded previously unreported interactions between multiple narwhals, Arctic char ( Salvelinus alpinus ) and glaucous gulls ( Larus hyperboreus ) in Canada...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
Impacts of Weather Anomalies and Climate on Plant DiseaseNARA Subscribed
Predicting the effects of climate change on plant disease is critical for protecting ecosystems and food production. Here, we show how disease pressure responds to short‐term weather, historical climate and weather anomalies by compiling a global database (4339 plant–disease populations) of disease prevalence in both agricultural and wild plant systems. We hypothesised that weather and climate would play a larger role in disea...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic. Neutralizing antibody (NAb) assays are used to characterize a positive anti-drug antibody (ADA) response. Harmonization of reporting of NAb assay performance and results enables efficient communication and expedient review by industry and health authorities. Herein, a cross-industry...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Comprehensive voxel-wise, tract-based, and network lesion mapping reveals unique architectures of right and left visuospatial neglectNARA Subscribed
Visuospatial neglect is a common, post-stroke cognitive impairment which is widely considered to be a disconnection syndrome. However, the patterns of disconnectivity associated with visuospatial neglect remain unclear. Here, we had 480 acute stroke survivors [age = 72.8 (SD = 13.3), 44.3% female, 7.5 days post-stroke (SD = 11.3)] undertake routine clinical imaging and standardised visuospatial neglect testing. The data were u...