A growing proportion of forested landscapes are interspersed with human infrastructure, such as utility lines and roads, increasing the potential for tree-failure consequences due to storms and other causes. Utilities and other institutions have strong incentives to reduce such interactions and allocate substantial resources to risk reduction, but trees and forests in densely populated landscapes also provide significant ameni...

G protein-coupled receptors strongly modulate neuronal excitability but there has been little evidence for G protein mechanisms in genetic epilepsies. Recently, four patients with epileptic encephalopathy (EIEE17) were found to have mutations in GNAO1, the most abundant G protein in brain, but the mechanism of this effect is not known. The GNAO1 gene product, Gα o , negatively regulates neurotransmitter release. Here, we repor...