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Building climate-smart fisheries in Australia: insights from climate and ecosystem status reportsNARA Subscribed
Ongoing concerns about the impact of climate change on Australia’s oceans has driven a request from fisheries managers for improved science communication to the seafood sector. Despite these concerns, translating climate science into management and industry action at regional and sectoral scales remains a challenge. We developed a reporting structure for communicating climate and ecosystem status to fisheries management, indus...
An experimental approach to assess the combined effects of multiple stressors on a large vertebrate speciesNARA Subscribed
The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure. The population of bottlenose dolphins in Barataria Bay, Louisiana, experienced long...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Repeated barrier drown-out is required to facilitate long-distance migration of a potamodromous fishNARA Subscribed
Migratory fish species are highly vulnerable to stream fragmentation. Potamodromous golden perch ( Macquaria ambigua ) inhabit the barrier-laden Murray–Darling Basin (MDB), Australia’s largest river system, and its lifecycle includes a requirement for uninterrupted stretches of flowing water habitat. Owing to these barriers, large-scale connectivity in many regions is limited to periods of high flow events that facilitate barr...
Environmental salinity differentially impacts branchial and hepatic carbohydrate metabolism in tilapiaNARA Subscribed
In response to changes in environmental salinity, euryhaline fishes mobilize energy to support the active transport of ions across osmoregulatory epithelia. Glycogen synthase (GS) and glycogen phosphorylase (GP) are key controllers of carbohydrate metabolism due to their roles in promoting glycogenesis and glycogenolysis, respectively. However, the coordinated responses of GS, GP and glucose transporters (GLUTs) in the liver a...
Oscillatory Dynamics Serving Verbal Working Memory Differ in People with HIV and Are Linked To Disease DurationNARA Subscribed
Background Medical advances have greatly improved the quality of life and extended the longevity of people with HIV (PWH). However, many PWH still develop neurocognitive deficits even in the presence of effective viral suppression, with impairments in verbal working memory (VWM) being among the most common. While previous neuroimaging studies have demonstrated altered neural responses during VWM, the underlying temporal dynami...