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Springer Nature1
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Molecular Neurobiology1
Publication Year
20221
Jayanth Anantha results 1 · Newest (Page 1/1, per page 25)
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NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s DiseaseNARA Subscribed
Molecular Neurobiology · 2022 · Vol. 59 · Issue 1 · Springer
Jayanth Anantha; Susan R. Goulding; Eszter Tuboly; Adam G. O’Mahony; Gerard M. Moloney; Gareth Lomansey; Cathal M. McCarthy; Louise M. Collins; Aideen M. Sullivan; Gerard W. O’Keeffe
Parkinson’s disease (PD) is a neurodegenerative disease characterised by the progressive degeneration of midbrain dopaminergic neurons, coupled with the intracellular accumulation of α-synuclein. Axonal degeneration is a central part of the pathology of PD. While the majority of PD cases are sporadic, some are genetic; the G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic form. The application...
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