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Aim The temperature‐size rule is often described as a reduction in ectothermic asymptotic or maximum body size with warming. Although this coincides with the expectation that faster growth under warming would lead to larger sizes early in life but smaller sizes later in life, there remain few tests of changes in size across ontogeny. Here, we use > 99,000 observations of weight‐at‐age of commercially important fishes over 25 y...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Mesoscale eddies play a critical role in mediating meridional transport across the Antarctic Circumpolar Current (ACC), yet the dynamics of cross-frontal eddies (CFEs) and their energy exchanges with frontal jets remain inadequately quantified. This study presents a systematic analysis of CFE characteristics, kinetic energy evolution, and thermohaline transport effects in the Pacific sector of the Southern Ocean, utilizing 23...
Community-engaged analysis of soil lead contamination near a historical metallurgy facility in Los Angeles, CaliforniaNARA Subscribed
Legacy industrial lead (Pb) contamination poses a public health problem worldwide. In Southeast Los Angeles, California, a history of concentrated industrial activity has raised concern about Pb contamination in the area’s neighborhoods, particularly in Huntington Park. One former industrial facility in Huntington Park has attracted attention from both a local community environmental justice organization and the U.S. Environme...
Technical Considerations of Pharmacokinetic Assays for LNP-mRNA Drug Products by RT-qPCRNARA Subscribed
Lipid nanoparticle-messenger RNA (LNP-mRNA) drug products are a growing class of drug modalities. The unique composition of these drug products requires multiple measurements to account for the different components of these drug modalities. Pharmacokinetic (PK) measurements include measurement of the encapsulated mRNA and components of the LNP in circulation to understand the effectiveness of the therapeutic mRNA. The PK measu...
Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease modelsNARA Subscribed
Alzheimer’s disease (AD) is an age-related disease, with loss of integrity of the blood–brain barrier (BBB) being an early feature. Cellular senescence is one of the reported nine hallmarks of aging. Here, we show for the first time the presence of senescent cells in the vasculature in AD patients and mouse models of AD. Senescent endothelial cells and pericytes are present in APP/PS1 transgenic mice but not in wild-type litte...
Assessing in vivo performance to inform formulation selection and development decisions is an important aspect of drug development. Biopredictive dissolution methodologies for oral dosage forms have been developed to understand in vivo performance, assist in formulation development/optimization, and forecast the outcome of bioequivalence studies by combining them with simulation tools to predict plasma profiles in humans. Howe...
The air mycobiome is decoupled from the soil mycobiome in the California San Joaquin ValleyNARA Subscribed
Dispersal is a key force in the assembly of fungal communities and the air is the dominant route of dispersal for most fungi. Understanding the dynamics of airborne fungi is important for determining their source and for helping to prevent fungal disease. This understanding is important in the San Joaquin Valley of California, which is home to 4.2 million people and where the airborne fungus Coccidioides is responsible for the...
Commercially available garden products as important sources of antibiotic resistance genes—a surveyNARA Subscribed
The dissemination of antibiotic resistance genes (ARGs) in the environment contributes to the global rise in antibiotic resistant infections. Therefore, it is of importance to further research the exposure pathways of these emerging contaminants to humans. This study explores commercially available garden products containing animal manure as a source of ARGs in a survey of 34 garden products, 3 recently landscaped soils, and 5...