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Springer Nature1
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Psychopharmacology1
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20241
Jeremy Metha results 1 · Newest (Page 1/1, per page 25)
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Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male miceNARA Subscribed
Psychopharmacology · 2024 · Vol. 241 · Issue 10 · Springer
Jeremy Metha; Yijun Ji; Clemens Braun; Janet R. Nicholson; Luis De Lecea; Carsten Murawski; Daniel Hoyer; Laura H. Jacobson
Rationale Motivation and inhibitory control are dominantly regulated by the dopaminergic (DA) and noradrenergic (NA) systems, respectively. Hypothalamic hypocretin (orexin) neurons provide afferent inputs to DA and NA nuclei and hypocretin-1 receptors (HcrtR1) are implicated in reward and addiction. However, the role of the HcrtR1 in inhibitory control is not well understood. Objectives To determine the effects of HcrtR1 antag...
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