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Advances in veterinary drug and vaccine delivery: from conventional delivery methods to innovative transdermal approachesNARA Subscribed
Veterinary drug delivery must balance efficacy, ease of administration, and animal welfare. Traditional methods, such as oral and injectable routes, pose challenges due to species-specific variations, stress during administration, and the need for repeated dosing. Emerging transdermal systems, particularly microneedle patches, offer a minimally invasive alternative that enhances drug absorption while reducing handling stress t...
This study aimed to generate evidence to support psychometric validity of the modified functional Scale for the Assessment and Rating of Ataxia (f-SARA) among patients with spinocerebellar ataxia (SCA). Psychometric measurement properties and minimal change thresholds of the f-SARA were evaluated using data from a cohort of SCA subjects (recruited at Massachusetts General Hospital [MGH]; n = 33) and data from a phase 3 trial o...
Spinocerebellar ataxias (SCA) are rare inherited neurodegenerative disorders characterized by a progressive impairment of gait, balance, limb coordination, and speech. There is currently no composite scale that includes multiple aspects of the SCA experience to assess disease progression and treatment effects. Applying the method of partial least squares (PLS) regression, we developed the Spinocerebellar Ataxia Composite Scale...
Pansteatitis is the leading cause for the decline in Nile crocodile populations and the sporadic mortality of fish in the Olifants River System, South Africa. To determine the prevalence of this disease in lentic systems, Mozambique tilapia, Oreochromis mossambicus , were collected from Lake Loskop, Lake Flag Boshielo, Phalaborwa Barrage and Lake Luphephe‐Nwanedi. The former three impoundments are located within the main stem...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
A survey of the region eastward of Nantucket provided an opportunity to examine the cold temperate–boreal boundary along the high‐energy Great South Channel. Here described are the benthic macroinvertebrate community types encountered, with a focus on the influence of climate change on the range boundaries of the benthic biomass dominants and the potential existence of transient multiple stable states. The survey identified th...
Numerous current efforts seek to improve the representation of ecosystem ecology and vegetation demographic processes within Earth System Models ( ESM s). These developments are widely viewed as an important step in developing greater realism in predictions of future ecosystem states and fluxes. Increased realism, however, leads to increased model complexity, with new features raising a suite of ecological questions that requi...
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