Distal cholangiocarcinoma (dCCA) is a malignant tumor characterized by a challenging diagnosis, high invasiveness, and extremely poor prognosis. Research on dCCA is limited by the scarcity of reliable patient-derived preclinical tumor models. This study established a novel human distal cholangiocarcinoma cell line, CBC3T-3, and systematically characterized its biological properties, genomic features, and potential for clinical...

Rising temperatures are projected to lead to a decline in global wheat production. However, this global trend belies the regional nuances of this impact, such as observed local yield increases in some field experiments in the winter wheat‐growing region of China. This study combines detailed data from eight field warming experiments and outputs of simulation by an ensemble of three point‐based crop models and an ensemble of 10...