Accurate timing of myelination is crucial for the proper functioning of the central nervous system. Here, we identified a de novo heterozygous mutation in TMEM63A (c.1894G>A; p. Ala632Thr) in a 7-year-old boy exhibiting hypomyelination. A Ca 2+ influx assay suggested that this is a loss-of-function mutation. To explore how TMEM63A deficiency causes hypomyelination, we generated Tmem63a knockout mice. Genetic deletion of TMEM63...

Despite intensive research, our understanding of how plants respond to warming by coordinating their full arsenal of traits to adjust fitness is lacking. To fill this gap, we applied a trait‐based framework with three clusters (two functional clusters: “carbon‐fixation rate” and “carbon‐fixation area”; a third cluster: “total carbon fixation”) to a global dataset compiled from 572 studies of warming experiments with 677 specie...

Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an increasing number of surgical procedures being performed, the prevention and management of perioperative neurocognitive dysfunction have garnered significant attention. While factors such as age, lifestyle, genetics, and education are known to influen...