The quality and uncertainty of training samples are a critical bottleneck constraining the performance of machine learning in landslide susceptibility mapping (LSM). To address this, this study introduces a sample purity optimization framework based on state-process consistency (SPC). The framework utilizes two indices, SWCFD and CF-BE-HMD, combined with a mutually exclusive stratified purity strategy (MESPS), to systematicall...

Notch signaling plays a pivotal role in regulating various developmental processes, particularly in controlling the timing of neuronal production within the developing neocortex. Central to this regulatory mechanism is the oscillatory pattern of Delta, which functions as a developmental clock modulator. Its deficiency profoundly impairs mammalian brain formation, highlighting its fundamental role in brain development. However,...

Hemorrhagic stroke is a global health problem owing to its high morbidity and mortality rates. Nicotinamide riboside is an important precursor of nicotinamide adenine dinucleotide characterized by a high bioavailability, safety profile, and robust effects on many cellular signaling processes. This study aimed to investigate the protective effects of nicotinamide riboside against collagenase-induced hemorrhagic stroke and its u...