In March 2024, a severe mass mortality event occurred at a grass carp ( Ctenopharyngodon idella ) farm in Zhejiang, China, resulting in a cumulative mortality rate of 70%. To identify the causative agent, 12 bacterial isolates that exhibited the same phenotypic characteristics were isolated from diseased fish. A further phylogenetic (16S rDNA) characterization identified the bacterium as Flavobacterium psychrophilum . Genetic...

Distal cholangiocarcinoma (dCCA) is a malignant tumor characterized by a challenging diagnosis, high invasiveness, and extremely poor prognosis. Research on dCCA is limited by the scarcity of reliable patient-derived preclinical tumor models. This study established a novel human distal cholangiocarcinoma cell line, CBC3T-3, and systematically characterized its biological properties, genomic features, and potential for clinical...

Vestibular efferent neurons in the brainstem provide direct cholinergic innervation to peripheral vestibular organs, thereby modulating their sensory responsiveness. In this study, a genetically targeted mouse model with choline acetyltransferase-driven fluorescent labeling enabled the precise localization of these neurons to the dorsolateral region of the genu of the facial nerve. Whole-cell patch-clamp recordings in acute br...

Upper oceans are highly energetic during a severe weather event, with large surface waves and intense ocean currents over areas affected by the storm. An advanced and coupled wave–current modelling system for the northwestern Atlantic (WCMS-NWA) was developed by the Regional Modelling Group at Dalhousie University for simulating surface waves and three-dimensional ocean currents over the eastern Canadian shelf and adjacent wat...