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The immunogenic potential of AZD1402 (Elarekibep) T-cell epitopes in healthy volunteers and drug-exposed clinical trial participantsNARA Subscribed
AZD1402 (Elarekibep) is a novel anticalin with engineered IL-4Rα antagonist binding properties that was under development for inhaled treatment of asthma. Structural similarity to tear-lipocalin is thought to limit immunogenicity risk; however, a range of treatment-emergent hypersensitivity-like adverse events were observed in a clinical study. This study aimed to (i) explore the activation of drug-exposed human T-cells with A...
Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brainNARA Subscribed
Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality’s invasive nature. This study substantially expands the subject pool compared to existing literature, to create a mult...
Dominance and rarity in tree communities across the globe: Patterns, predictors and threatsNARA Subscribed
Aim Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree...
Aim To determine the relationships between the functional trait composition of forest communities and environmental gradients across scales and biomes and the role of species relative abundances in these relationships. Location Global. Time period Recent. Major taxa studied Trees. Methods We integrated species abundance records from worldwide forest inventories and associated functional traits (wood density, specific leaf area...
Native ash species in the central hardwood region of the United States have been threatened by infestations of emerald ash borers (EAB), which have caused significant damage to the forests’ ecological and economic value. Because private landowners own most of these forestlands, their knowledge, attitudes, and behavior are important in managing EAB effectively across the landscape. We conducted a mail survey of landowners in Ke...
Understanding Forest Landowner Attitudes, Perceived Risk, and Response to Emerald Ash Borer in KentuckyNARA Subscribed
Emerald ash borer (EAB) (Agrilus planipennis), an invasive nonnative beetle, is responsible for the mortality of ash trees in the eastern and midwestern United States. Despite efforts to contain this beetle through various control options, human-induced spread of EAB has caused damage to ash forests in many states. Because most ash trees are under private ownership, it is important to understand how landowners evaluate the ris...
Climate change is affecting the health and physiology of marine organisms and altering species interactions. Ocean acidification ( OA ) threatens calcifying organisms such as the Pacific oyster, Crassostrea gigas . In contrast, seagrasses, such as the eelgrass Zostera marina , can benefit from the increase in available carbon for photosynthesis found at a lower seawater pH . Seagrasses can remove dissolved inorganic carbon fro...
Forest Policy / BiosecurityNARA Subscribed
7Massive fires in Indonesian peatlands in the 1990s and in eastern Russian peatlands in 2002 and last year have highlighted the need to manage forests overlying peat deposits, as well as converted peat forests and open peatlands. Peat or peaty soils, contain 65% or more of partially decayed vegetation, can burn freely or underground. They cover some 10 percent of worldwide forests and contain 25 percent of all terrestrial carb...
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