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Antibiotics cause significant gut microbiome dysbiosis, particularly when administered orally. This contributes to antimicrobial resistance (AMR) and is associated with myriad health conditions. Novel drug delivery strategies that minimize gut exposure while maintaining therapeutic efficacy are urgently needed. This study aimed to evaluate whether a novel transdermal system could reduce gut microbiome disruption compared to or...
Evaluating the evidence for the ecological relevance and adaptive potential of limb-length plasticity in Anolis lizardsNARA Subscribed
Whether phenotypic plasticity facilitates adaptive evolution is a key question in evolutionary ecology. The discovery of limb-length plasticity in two Anolis lizard species led to hypotheses about its role in the Anolis radiation. Yet, whether limb plasticity is realized in nature and has adaptive significance is poorly understood. In this study, we combined a limb-length plasticity experiment, lab-based assays of hatchling be...
The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant BacteriaNARA Subscribed
Antimicrobial resistance (AMR) is shaped by environmental pressures, yet the role of microbial predators such as Acanthamoeba in resistance dynamics remains poorly characterized. In this study, Acanthamoeba ‐associated bacterial communities (AAB) exhibited significantly higher multidrug resistance than sediment‐associated bacterial communities (SAB) in a polluted estuarine system. All isolated amoebae belonged to the T4 genoty...
The migratory behavior of Atlantic salmon ( Salmo salar ) post‐smolts in coastal waters is poorly understood. In this collaborative study, 1914 smolts, from 25 rivers, in four countries were tagged with acoustic transmitters during a single seasonal migration. In total, 1105 post‐smolts entered the marine study areas and 438 (39.6%) were detected on a network of 414 marine acoustic receivers and an autonomous underwater vehicl...
Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adultsNARA Subscribed
Vascular Endothelial Growth Factor A (VEGF-A) is an angiogenic signaling protein involved in the maintenance of the cerebral vasculature. No prior study has explored whether plasma VEGF-A levels may be associated with brain functional connectivity changes, such as disruption of the default mode network (DMN), which often precedes the development of cognitive changes in aging. Seventy-six independently living older adults (mean...
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adultsNARA Subscribed
Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory decline in older adults. Beat-to-beat BPV may represent a more reliable and efficient tool for prospective risk assessment, but it is unknown whether beat-to-beat BPV is similarly associated with hippocampal neurodegeneration, or with plasma markers of neuroaxonal/neuroglial injury. Independently living older...
Modeling genetic benefits and financial costs of integrating biobanking into the conservation breeding of managed marsupialsNARA Subscribed
Managed breeding programs are an important tool in marsupial conservation efforts but may be costly and have adverse genetic effects in unavoidably small captive colonies. Biobanking and assisted reproductive technologies (ARTs) could help overcome these challenges, but further demonstration of their potential is required to improve uptake. We used genetic and economic models to examine whether supplementing hypothetical capti...
Summary Chemolithoautotrophic bacteria from the genera Hydrogenovibrio, Thiomicrorhabdus and Thiomicrospira are common, sometimes dominant, isolates from sulfidic habitats including hydrothermal vents, soda and salt lakes and marine sediments. Their genome sequences confirm their membership in a deeply branching clade of the Gammaproteobacteria . Several adaptations to heterogeneous habitats are apparent. Their genomes include...