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Jolyon Mitchell results 28 · Newest (Page 1/2, per page 25)
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The Fundamentals of the Analysis of Cascade Impactor Data for the Characterization of Aerodynamic Particle Size Distributions (APSDs) in the Testing of Orally Inhaled Drug Products (OIPs)NARA Subscribed
AAPS PharmSciTech · 2025 · Vol. 26 · Issue 8 · Springer
Daryl L. Roberts; Jolyon P. Mitchell
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Proposals for Global Harmonization of Regulations for Testing of Spacers and Valved Holding Chambers for Pressurized Metered Dose InhalersNARA Subscribed
AAPS PharmSciTech · 2025 · Vol. 26 · Issue 5 · Springer
Jolyon P. Mitchell
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Laboratory Performance Testing of Aqueous Nasal Inhalation Products for Droplet/Particle Size Distribution: an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS)NARA Subscribed
AAPS PharmSciTech · 2023 · Vol. 24 · Issue 7 · Springer
William H. Doub; Julie M. Suman; Mark Copley; Adrian P. Goodey; Sana Hosseini; Jolyon P. Mitchell
Although nasal inhalation products are becoming more and more important for the delivery of medicines, characterization of these products for quality control and assessment of bioequivalence is complicated. Most of the problems encountered are associated with the assessment of aerodynamic droplet/particle size distribution (APSD). The droplets produced by the various nasal devices are large, and for suspension products, indivi...
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Good Practices for the Laboratory Performance Testing of Aqueous Oral Inhaled Products (OIPs): an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS)NARA Subscribed
AAPS PharmSciTech · 2023 · Vol. 24 · Issue 3 · Springer
Jolyon P. Mitchell; I. Carter; J. D. Christopher; M. Copley; W. H. Doub; A. Goodey; C. J. Gruenloh; B. B. Larson; S. Lyapustina; R. B. Patel; S. W. Stein; J. D. Suman
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Addressing the Need for Controls on Particle Bounce and Re-entrainment in the Cascade Impactor and for the Mitigation of Electrostatic Charge for Aerodynamic Particle Size Assessment of Orally Inhaled Products: an Assessment by the International Consortium on Regulation and Science (IPAC-RS)NARA Subscribed
AAPS PharmSciTech · 2020 · Vol. 21 · Issue 7 · Springer
William Doub; Stephen Stein; Jolyon Mitchell; Adrian P. Goodey
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Determination of Passive Dry Powder Inhaler Aerodynamic Particle Size Distribution by Multi-Stage Cascade Impactor: International Pharmaceutical Aerosol Consortium on Regulation & Science (IPAC-RS) Recommendations to Support Both Product Quality Control and Clinical ProgramsNARA Subscribed
AAPS PharmSciTech · 2019 · Vol. 20 · Issue 5 · Springer
Jolyon P. Mitchell; Stephen W. Stein; William Doub; Adrian P. Goodey; J. David Christopher; Rajni B. Patel; Terrence P. Tougas; Svetlana Lyapustina
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Measurement of Aerodynamic Particle Size Distribution of Orally Inhaled Products by Cascade Impactor: How to Let the Product Specification Drive the Quality Requirements of the Cascade ImpactorNARA Subscribed
AAPS PharmSciTech · 2019 · Vol. 20 · Issue 2 · Springer
Daryl L. Roberts; Jolyon P. Mitchell
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Evaluation of Nasal Inlet Ports Having Simplified Geometry for the Pharmacopeial Assessment of Mass Fraction of Dose Likely to Penetrate Beyond the Nasopharynx: a Preliminary InvestigationNARA Subscribed
AAPS PharmSciTech · 2018 · Vol. 19 · Issue 8 · Springer
Gerallt Williams; Chris Blatchford; Jolyon P. Mitchell
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Laboratory Study Comparing Pharmacopeial Testing of Nebulizers with Evaluation Based on Nephele Mixing Inlet MethodologyNARA Subscribed
AAPS PharmSciTech · 2018 · Vol. 19 · Issue 2 · Springer
Mårten Svensson; Elna Berg; Jolyon Mitchell; Dennis Sandell
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Discriminating Ability of Abbreviated Impactor Measurement Approach (AIM) to Detect Changes in Mass Median Aerodynamic Diameter (MMAD) of an Albuterol/Salbutamol pMDI AerosolNARA Subscribed
AAPS PharmSciTech · 2017 · Vol. 18 · Issue 8 · Springer
J . David Christopher; Rajni B. Patel; Jolyon P. Mitchell; Terrence P. Tougas; Adrian P. Goodey; Jorge Quiroz; Patrik U. Andersson; Svetlana Lyapustina
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Development and Evaluation of a Family of Human Face and Upper Airway Models for the Laboratory Testing of Orally Inhaled ProductsNARA Subscribed
AAPS PharmSciTech · 2017 · Vol. 18 · Issue 8 · Springer
Mark W. Nagel; Jason A. Suggett; Dominic P. Coppolo; Jolyon P. Mitchell
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A Comparison of the Performance of Efficient Data Analysis Versus Fine Particle Dose as Metrics for the Quality Control of Aerodynamic Particle Size Distributions of Orally Inhaled PharmaceuticalsNARA Subscribed
AAPS PharmSciTech · 2017 · Vol. 18 · Issue 2 · Springer
Terrence P. Tougas; Adrian P. Goodey; Gareth Hardwell; Jolyon Mitchell; Svetlana Lyapustina
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A Multi-laboratory in Vitro Study to Compare Data from Abbreviated and Pharmacopeial Impactor Measurements for Orally Inhaled Products: a Report of the European Aerosol Group (EPAG)NARA Subscribed
AAPS PharmSciTech · 2016 · Vol. 17 · Issue 6 · Springer
Steven C. Nichols; Jolyon P. Mitchell; Dennis Sandell; Patrik U. Andersson; Manfred Fischer; Markus Howald; Roy Pengilley; Phillip Krüger
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Clinically Relevant In Vitro Testing of Orally Inhaled Products—Bridging the Gap Between the Lab and the PatientNARA Subscribed
AAPS PharmSciTech · 2016 · Vol. 17 · Issue 4 · Springer
Jolyon P. Mitchell; Jason Suggett; Mark Nagel
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Developing Ways to Evaluate in the Laboratory How Inhalation Devices Will Be Used by Patients and Care-Givers: The Need for Clinically Appropriate TestingNARA Subscribed
AAPS PharmSciTech · 2014 · Vol. 15 · Issue 5 · Springer
Jolyon P. Mitchell; Jason A. Suggett
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Investigation of Dry Powder Inhaler (DPI) Resistance and Aerosol Dispersion Timing on Emitted Aerosol Aerodynamic Particle Sizing by Multistage Cascade Impactor when Sampled Volume Is Reduced from Compendial Value of 4 LNARA Subscribed
AAPS PharmSciTech · 2014 · Vol. 15 · Issue 5 · Springer
Hlack Mohammed; Jan Arp; Frank Chambers; Mark Copley; Volker Glaab; Mark Hammond; Derek Solomon; Kerry Bradford; Theresa Russell; Yvonne Sizer; Steven C. Nichols; Daryl L. Roberts; Christopher Shelton; Roland Greguletz; Jolyon P. Mitchell
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Challenges with Developing In Vitro Dissolution Tests for Orally Inhaled Products (OIPs)NARA Subscribed
AAPS PharmSciTech · 2012 · Vol. 13 · Issue 3 · Springer
Trevor Riley; David Christopher; Jan Arp; Andrea Casazza; Agnes Colombani; Andrew Cooper; Monisha Dey; Janet Maas; Jolyon Mitchell; Maria Reiners; Nastaran Sigari; Terrence Tougas; Svetlana Lyapustina
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Effect of Sampling Volume on Dry Powder Inhaler (DPI)-Emitted Aerosol Aerodynamic Particle Size Distributions (APSDs) Measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI)NARA Subscribed
AAPS PharmSciTech · 2012 · Vol. 13 · Issue 3 · Springer
Hlack Mohammed; Daryl L. Roberts; Mark Copley; Mark Hammond; Steven C. Nichols; Jolyon P. Mitchell
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Non-impactor-Based Methods for Sizing of Aerosols Emitted from Orally Inhaled and Nasal Drug Products (OINDPs)NARA Subscribed
AAPS PharmSciTech · 2011 · Vol. 12 · Issue 3 · Springer
Jolyon Mitchell; Richard Bauer; Svetlana Lyapustina; Terrence Tougas; Volker Glaab
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Product Lifecycle Approach to Cascade Impaction MeasurementsNARA Subscribed
AAPS PharmSciTech · 2011 · Vol. 12 · Issue 1 · Springer
Terrence P. Tougas; Dave Christopher; Jolyon Mitchell; Svetlana Lyapustina; Michiel Van Oort; Richard Bauer; Volker Glaab
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Relative Precision of Inhaler Aerodynamic Particle Size Distribution (APSD) Metrics by Full Resolution and Abbreviated Andersen Cascade Impactors (ACIs): Part 2—Investigation of Bias in Extra-Fine Mass Fraction with AIM-HRT ImpactorNARA Subscribed
AAPS PharmSciTech · 2010 · Vol. 11 · Issue 3 · Springer
Jolyon P. Mitchell; Mark W. Nagel; Cathy C. Doyle; Rubina S. Ali; Valentina I. Avvakoumova; J. David Christopher; Jorge Quiroz; Helen Strickland; Terrence Tougas; Svetlana Lyapustina
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Relative Precision of Inhaler Aerodynamic Particle Size Distribution (APSD) Metrics by Full Resolution and Abbreviated Andersen Cascade Impactors (ACIs): Part 1NARA Subscribed
AAPS PharmSciTech · 2010 · Vol. 11 · Issue 2 · Springer
Jolyon P. Mitchell; Mark W. Nagel; Cathy C. Doyle; Rubina S. Ali; Valentina I. Avvakoumova; J. David Christopher; Jorge Quiroz; Helen Strickland; Terrence Tougas; Svetlana Lyapustina
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Cascade Impactor (CI) Mensuration—An Assessment of the Accuracy and Precision of Commercially Available Optical Measurement SystemsNARA Subscribed
AAPS PharmSciTech · 2010 · Vol. 11 · Issue 1 · Springer
Frank Chambers; Aziz Ali; Jolyon Mitchell; Christopher Shelton; Steve Nichols
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Improved Quality Control Metrics for Cascade Impaction Measurements of Orally Inhaled Drug Products (OIPs)NARA Subscribed
AAPS PharmSciTech · 2009 · Vol. 10 · Issue 4 · Springer
Terrence P. Tougas; David Christopher; Jolyon P. Mitchell; Helen Strickland; Bruce Wyka; Mike Van Oort; Svetlana Lyapustina
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Minimizing Variability of Cascade Impaction Measurements in Inhalers and NebulizersNARA Subscribed
AAPS PharmSciTech · 2008 · Vol. 9 · Issue 2 · Springer
Matthew Bonam; David Christopher; David Cipolla; Brent Donovan; David Goodwin; Susan Holmes; Svetlana Lyapustina; Jolyon Mitchell; Steve Nichols; Gunilla Pettersson; Chris Quale; Nagaraja Rao; Dilraj Singh; Terrence Tougas; Mike Van Oort; Bernd Walther; Bruce Wyka
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