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Geographic information systems (GIS) have become central to applied spatial work, yet the structure and recent trajectory of master’s education in geographic information science and technology (GIS&T) in the United States remain underexplored. This study analyzes degree completion data from the Integrated Postsecondary Education Data System (IPEDS) between 2012 and 2024, drawing upon the Central Improvement Program (CIP)-based...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C DiseaseNARA Subscribed
Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...
Aim Plant leaf size and shape vary across major climatic gradients, reflecting the mechanisms for how plants regulate the balance of carbon, water, and heat. However, the influence of climate on leaf traits can be confounded by multiple factors, and the complex variation among different plant groups remains insufficiently understood. Here, we investigated how climate influences leaf size traits and whether this effect is moder...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...