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Identification of Cell Fate Determining Transcription Factors for Generating Brain Endothelial CellsNARA Subscribed
Reliable models of the blood-brain barrier (BBB), wherein brain microvascular endothelial cells (BMECs) play a key role in maintenance of barrier function, are essential tools for developing therapeutics and disease modeling. Recent studies explored generating BMEC-like cells from human pluripotent stem cells (hPSCs) by mimicking brain-microenvironment signals or genetic reprogramming. However, due to the lack of comprehensive...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
The Australian mixed-mode observing programNARA Subscribed
Global geodetic VLBI is upgrading to its next-generation observing system, VGOS. This upgrade has turned out to be a process over multiple years, until VGOS reaches its full capabilities with the envisaged continuous observations. Until then, for the Australian stations, the upgrade means ceasing their legacy S/X observations, leaving a large gap in the global network as well as in the station time series. The Australian mixed...
Dermal delivery of amitriptyline for topical analgesiaNARA Subscribed
Amitriptyline, administered orally, is currently one of the treatment options for the management of neuropathic pain and migraine. Because of the physicochemical properties of the molecule, amitriptyline is also a promising candidate for delivery as a topical analgesic. Here we report the dermal delivery of amitriptyline from a range of simple formulations. The first stage of the work required the conversion of amitriptyline h...
Multimodel approaches in shark and ray growth studies: strengths, weaknesses and the futureNARA Subscribed
Multimodel frameworks are common in contemporary elasmobranch growth literature. These techniques offer a proposed improvement over individual growth functions by incorporating additional candidate models with alternative characteristics. Sigmoid functions (e.g. Gompertz and logistic) are a popular alternative to the commonly used von Bertalanffy growth function ( VBGF ) as they are hypothesized to better suit certain taxa bas...
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