Jonathan Newman results 36
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Robust species distribution predictions of predator and prey responses to climate changeNARA Subscribed
Aim Species distribution models (SDMs) can be correlative or mechanistic, which have very different assumptions, leading to potentially different estimates of the ecological niches and distributions of the species. The model predictions from correlative and mechanistic approaches are incomparable due to their distinct assumptions. Yet, seeking their agreements can identify robust predictions that are relatively independent of...
Population genomic structure of a widespread, urban‐dwelling mammal: The eastern grey squirrel ( Sciurus carolinensis )NARA Subscribed
Urbanization is a persistent and widespread driver of global environmental change, potentially shaping evolutionary processes due to genetic drift and reduced gene flow in cities induced by habitat fragmentation and small population sizes. We tested this prediction for the eastern grey squirrel ( Sciurus carolinensis ), a common and conspicuous forest‐dwelling rodent, by obtaining 44K SNPs using reduced representation sequenci...
Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer’s Disease ModelsNARA Subscribed
We have previously shown that histone deacetylase (HDAC) inhibition and cranial radiotherapy (RT) independently improve molecular and behavioral Alzheimer’s disease (AD)-like phenotypes. In the present study, we investigate the synergistic potential of using both RT and HDACi as a low-dose combination therapy (LDCT) to maximize disease modification (reduce neuroinflammation and amyloidogenic APP processing, increase neurotroph...
Cancer microenvironment and genomics: evolution in processNARA Subscribed
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Using structured eradication feasibility assessment to prioritize the management of new and emerging invasive alien species in EuropeNARA Subscribed
Prioritizing the management of invasive alien species (IAS) is of global importance and within Europe integral to the EU IAS regulation. To prioritize management effectively, the risks posed by IAS need to be assessed, but so too does the feasibility of their management. While the risk of IAS to the EU has been assessed, the feasibility of management has not. We assessed the feasibility of eradicating 60 new (not yet establish...
Global environmental change effects on plant community composition trajectories depend upon management legaciesNARA Subscribed
The contemporary state of functional traits and species richness in plant communities depends on legacy effects of past disturbances. Whether temporal responses of community properties to current environmental changes are altered by such legacies is, however, unknown. We expect global environmental changes to interact with land‐use legacies given different community trajectories initiated by prior management, and subsequent re...
Drivers of temporal changes in temperate forest plant diversity vary across spatial scalesNARA Subscribed
Global biodiversity is affected by numerous environmental drivers. Yet, the extent to which global environmental changes contribute to changes in local diversity is poorly understood. We investigated biodiversity changes in a meta‐analysis of 39 resurvey studies in European temperate forests (3988 vegetation records in total, 17–75 years between the two surveys) by assessing the importance of (i) coarse‐resolution (i.e., among...
Climate and host plant availability impact the future distribution of the bean leaf beetle ( Cerotoma trifurcata )NARA Subscribed
The bean leaf beetle, Cerotoma trifurcata , has become a major pest of soybean throughout its North American range. With a changing climate, there is the potential for this pest to further expand its distribution and become an increasingly severe pest in certain regions. To examine this possibility, we developed bioclimatic envelope models for both the bean leaf beetle, and its most important agronomic host plant, soybean ( Gl...
Climate change and voltinism in C alifornian insect pest species: sensitivity to location, scenario and climate model choiceNARA Subscribed
Experimental studies of the impact of climatic change are hampered by their inability to consider multiple climate change scenarios and indeed often consider no more than simple climate sensitivity such as a uniform increase in temperature. Modelling efforts offer the ability to consider a much wider range of realistic climate projections and are therefore useful, in particular, for estimating the sensitivity of impact predict...
Climate change may dramatically affect the distribution and abundance of organisms. With the world's population size expected to increase significantly during the next 100 years, we need to know how climate change might impact our food production systems. In particular, we need estimates of how future climate might alter the distribution of agricultural pests. We used the climate projections from two general circulation models...