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Methylation array signals are predictive of chronological age without bisulfite conversionNARA Subscribed
DNA methylation data has been used to make “epigenetic clocks” which attempt to measure chronological and biological aging. These models rely on data derived from bisulfite-based measurements, which exploit a semi-selective deamination and a genomic reference to determine methylation states. We found that non-methylation factors lead to “pseudomethylation” signals that are both confounding of epigenetic clocks and uniquely age...
The Inhibition and Variability of Two Different RT-qPCR Assays Used for Quantifying SARS-CoV-2 RNA in WastewaterNARA Subscribed
Faecal shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its subsequent detection in wastewater turned the spotlight onto wastewater-based epidemiology (WBE) for monitoring the coronavirus-disease 2019 (COVID-19) pandemic. WBE for SARS-CoV-2 has been deployed in 70 countries, providing insights into disease prevalence, forecasting and the spatiotemporal tracking and emergence of SARS-CoV-2 variants....
Winter climate warming is rapidly leading to changes in snow depth and soil temperatures across mid‐ and high‐latitude ecosystems, with important implications for survival and distribution of species that overwinter beneath the snow. Amphibians are a particularly vulnerable group to winter climate change because of the tight coupling between their body temperature and metabolic rate. Here, we used a mechanistic microclimate mo...
Value of protected areas to avian persistence across 20 years of climate and land‐use changeNARA Subscribed
Establishing protected areas, where human activities and land cover changes are restricted, is among the most widely used strategies for biodiversity conservation. This practice is based on the assumption that protected areas buffer species from processes that drive extinction. However, protected areas can maintain biodiversity in the face of climate change and subsequent shifts in distributions have been questioned. We evalua...
Applying species distribution modelling to a data poor, pelagic fish complex: the ocean sunfishesNARA Subscribed
Aim Conservation management of vulnerable species requires detailed knowledge of their spatial and temporal distribution patterns. Within this context, species distribution modelling ( SDM ) can provide insights into the spatial ecology of rarely encountered species and is used here to explore the distribution pattern of ocean sunfishes ( Mola mola and M. ramsayi ). Both species are prone to high levels of bycatch and are clas...
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