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Climate‐driven alterations in sea‐ice dynamics and shifting fishing activity are reshaping ecosystems across the Arctic and Antarctic, yet conservation‐relevant information for chondrichthyans (sharks, rays, and chimaeras) remains limited. We present the first assessment of Important Shark and Ray Areas (ISRAs) across Polar Waters, integrating species distributions, extinction risk, critical habitat evidence, spatial protectio...
An experimental approach to assess the combined effects of multiple stressors on a large vertebrate speciesNARA Subscribed
The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure. The population of bottlenose dolphins in Barataria Bay, Louisiana, experienced long...
Antibiotics cause significant gut microbiome dysbiosis, particularly when administered orally. This contributes to antimicrobial resistance (AMR) and is associated with myriad health conditions. Novel drug delivery strategies that minimize gut exposure while maintaining therapeutic efficacy are urgently needed. This study aimed to evaluate whether a novel transdermal system could reduce gut microbiome disruption compared to or...
From kelp forests to turf reefs: Patterns, drivers, and impacts to functional diversityNARA Subscribed
Kelp forests are declining in many regions due to ocean warming, predator loss, and other anthropogenic stressors. In areas of rapid ocean warming, including the southern Gulf of Maine, these ecosystems have transitioned to a novel state dominated by low‐lying mats of turf algae. However, the pace, drivers, and ecological consequences of this transition remain unclear. Here, we used field surveys from 32 sites over 5 years (20...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaineNARA Subscribed
Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults. It places a significant burden on healthcare systems due to high medication costs and long-term care needs. Implantable devices offer a promising alternative for delivering sustained drug doses in the treatment of chronic conditions. This study introduces a novel long-acting subcutaneous implant for dual-d...