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Springer Nature1
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GeroScience1
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20251
Joshua Barkin results 1 · Newest (Page 1/1, per page 25)
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Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balanceNARA Subscribed
GeroScience · 2025 · Springer
Tian Tian; Yuhua Xue; Zhewei Song; Brady Jin-Smith; Joshua Barkin; Melak Ottallah; Mahfuza Mannan; Arina Zhirkova; Daohong Zhou; Liya Pi
The liver is one of the organs most affected by alcohol consumption, and its interaction with aging is particularly significant. Chronic alcohol consumption accelerates liver aging through mechanisms such as oxidative stress, inflammation, fibrosis, and impaired regeneration. It is still unknown whether senescent cell clearance orchestrates innate and adaptive immune responses during the alcohol-induced old liver damage proces...
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