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The conduction velocity-potassium relationship in the heart is modulated by sodium and calciumNARA Subscribed
The relationship between cardiac conduction velocity (CV) and extracellular potassium (K + ) is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV. Recent studies from our group suggest that elevating extracellular sodium (Na + ) and calcium (Ca 2+ ) can enhance CV by an extracellular pathway parallel to gap junctional coupling (GJC) called ephaptic coupling that can occur in the gap junction a...
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