The sabre‐toothed blennies (tribe Nemophini) are renowned for vivid colouration and several evolutionary adaptations, including a venom that resembles opioids in both chemistry and function. The genus Plagiotremus contains 11 species distributed across the Indo‐Pacific and Red Sea, including two nominal species endemic to Hawai'i. Here, we use mitochondrial COI and cytb in addition to select morphological characters to examine...

Local drug delivery systems (LDDS) are a promising method to overcome challenges associated with chemotherapeutic treatment of brain tumours, namely poor blood-brain barrier penetration. Here we report a poly(ethyleneglycol)-poly(lactide)-poly(caprolactone)-poly(lactide)-poly(ethyleneglycol) based injectable hydrogel, PELCLE, loaded with Doxorubicin (Dox) and Olaparib (Ola) as an LDDS against glioblastoma (GBM), a primary mali...

Identifying populations at highest risk from climate change is a critical component of conservation efforts. However, vulnerability assessments are usually applied at the species level, even though intraspecific variation in exposure, sensitivity and adaptive capacity play a crucial role in determining vulnerability. Genomic data can inform intraspecific vulnerability by identifying signatures of local adaptation that reflect...

Thermal breadth ( T br ) is a critical trait influencing organisms' response to climate change. Three hypotheses seek to explain interspecific and interpopulation variation in T br , each relying on a different temperature driver: Climate Variability Hypothesis (CVH)–annual temperature range; Thermal Constraints Hypothesis (TCH)–mean annual temperature; and Diel Narrowing Hypothesis (DNH)–mean diel temperature range. We test t...

The tope ( Galeorhinus galeus , Linnaeus, 1758) is a critically endangered shark, which, like numerous elasmobranchs, faces severe global decline. There are, however, substantial disparities between this species' global conservation status and those of some local populations, with the Northeast Atlantic representing a relative stronghold for this species. However, several areas of uncertainty, particularly regarding individual...