K. Crowe results 27
· Newest (Page 1/2, per page 25)
Author: K. Crowe ×Clear All Filters
Search Results
Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes ProjectNARA Subscribed
Background Genome sequencing was first offered clinically in the UK through the 100,000 Genomes Project (100KGP). Analysis was restricted to predefined gene panels associated with the patient’s phenotype. However, panels rely on clearly characterised phenotypes and risk missing diagnoses outside of the panel(s) applied. We propose a complementary method to rapidly identify pathogenic variants, including those missed by 100KGP...
About a third of all marine fish in the world are caught in Small-Scale Fisheries (SSF). SSF are increasingly recognised as essential for food security and livelihoods for vulnerable and economically fragile communities globally. Although individual SSF vessels are usually perceived as having little impact on the ecosystem, the cumulative impact of gear type and number of vessels may be substantial. Bottom trawling is a common...
The critically endangered North Atlantic right whale population ( Eubalaena glacialis ) has experienced multiple periods of decreased reproduction within its observable history, which have played a role in the overall decline of the species. In addition to this synchronized variation in reproduction across the population, there exists considerable individual variation in fecundity. To determine the impacts of family history an...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
In this paper, we outline the need for a coordinated international effort toward the building of an open-access Global Ocean Oxygen Database and ATlas (GO 2 DAT) complying with the FAIR principles (Findable, Accessible, Interoperable, and Reusable). GO 2 DAT will combine data from the coastal and open ocean, as measured by the chemical Winkler titration method or by sensors (e.g., optodes, electrodes) from Eulerian and Lagrang...
Mortality is a demographic metric crucial for understanding the dynamics of endangered populations such as Cook Inlet beluga whales (CIBWs, Delphinapterus leucas ), but patterns of mortality are currently not well understood for CIBWs, making decisions about recovery actions challenging. We combined long‐term photo‐ID data from approximately 420 individual belugas identified during the period 2005–2017 with stranding data from...
A global analysis of complexity–biodiversity relationships on marine artificial structuresNARA Subscribed
Aim Topographic complexity is widely accepted as a key driver of biodiversity, but at the patch‐scale, complexity–biodiversity relationships may vary spatially and temporally according to the environmental stressors complexity mitigates, and the species richness and identity of potential colonists. Using a manipulative experiment, we assessed spatial variation in patch‐scale effects of complexity on intertidal biodiversity. Lo...
Short‐term survival of Steller sea lion ( Eumetopias jubatus ) pups: Investigating the effect of health status on survivalNARA Subscribed
We estimated survival probabilities for Steller sea lion ( Eumetopias jubatus ) pups from 3 wk to 6 wk old and from 6 wk to 1 yr at three rookeries in southeastern Alaska. We also investigated the effect of mass, body condition, health variables, and the genetic origin on 3–6 wk survival. Survival differed substantially among rookeries and between sexes, with survival lowest at Hazy Islands, intermediate at White Sisters, and...
HIV eradication symposium: will the brain be left behind?NARA Subscribed
Diet of Pacific sleeper shark, a potential Steller sea lion predator, in the north‐east Pacific OceanNARA Subscribed
Pacific sleeper sharks Somniosus pacificus were captured near Steller sea lion Eumetopias jubatus rookeries during the period when Steller sea lion pups are most vulnerable to Pacific sleeper shark predation (first water entrance and weaning). Analysis of stomach contents revealed that teleosts were the dominant prey in August and cephalopods were the dominant prey in May ( n = 198). Marine mammals were found in 15% of stomach...
Middle Pleistocene interglacial deposits at Barling, Essex, England: evidence for a longer chronology for the Thames terrace sequenceNARA Subscribed
Results are presented from a multidisciplinary study of fossiliferous interglacial deposits on the northern side of the Thames estuary. These fill a channel cut into London Clay bedrock and overlain by the Barling Gravel, a Thames–Medway deposit equivalent to the Lynch Hill and Corbets Tey Gravels of the Middle and Lower Thames, respectively. The channel sediments yielded diverse molluscan and ostracod assemblages, both implyi...
LettersNARA Subscribed
LettersNARA Subscribed