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Wild bees occupy temporally stable pollen nutritional nichesNARA Subscribed
As bees’ primary source of protein and lipids, pollen is a nutritional resource key to the persistence of wild populations. Because bee taxa may differ in their pollen macronutrient requirements, and pollen is a limited resource that varies chemically across plants, nutritional niches may shape bees’ ecological interactions. To explore whether members of bee communities occupy pollen nutritional niches, we analysed the protein...
PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticalsNARA Subscribed
The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Influence of surgical intervention on pre- and post-surgery patient specific muscle synergies in children with cerebral palsyNARA Subscribed
Muscle synergy analysis has been explored as means to better understand changes in motor control, with the aim to improve treatment outcomes after Single Event Multilevel Surgery (SEMLS) for children with cerebral palsy (CP). In this single-group study, we assess changes between pre- and post-surgery muscle synergies at both patient specific, and cohort levels after surgical intervention for children with CP. We analysed the w...
Sepsis survivors frequently experience post-discharge physical function decline and encounter logistical barriers to participation in traditional outpatient rehabilitation. This pilot study examined the feasibility, safety, and preliminary efficacy of a remotely delivered, home-based exercise program on physical function in older sepsis survivors. In this single-blinded, randomized controlled trial (RCT), sepsis survivors aged...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...