K. Ross results 259
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Purpose Exercise can reduce C-reactive protein (CRP), but heterogeneity exists and it is unclear whether exercise-induced weight compensation occurs or relates to CRP change. We examined whether compensation occurs in adults with elevated CRP during exercise and whether compensation and compensatory behaviours are associated with CRP change. Methods In this 4-month randomised controlled trial, 124 sedentary adults with elevate...
Calibration of the species threat abatement and restoration metric's threat abatement component in a Costa Rican landscapeNARA Subscribed
Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species. STAR scores quantify the potential contribution of actions to abate threats and restore habitat to reduce species extinction risk in a particular place and can...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitisNARA Subscribed
Fungal keratitis (FK), caused by fungi like Aspergillus , Fusarium , and Candida , accounts for 20–60% of microbial keratitis cases and over 1 million visual impairments annually. Voriconazole (VOR) is effective against FK, but its eye drop formulations suffer from poor bioavailability, while intrastromal injections are invasive and carry risks. This study aimed to address these challenges by formulating a VOR nanosuspension (...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Arctic is warming at an unprecedented rate and with longer growing seasons, greater rainfall, and less snowfall. Cold-adapted ectotherms, such as the Arctic charr, Salvelinus alpinus (Linnaeus 1758), are likely to experience changes to growth as a result. Anadromous Arctic charr (charr, hereafter) are of great importance for northern communities, providing a source of income from commercial fisheries and food security from...
Annual Temperature Range Drives Thermal Breadth of Freshwater Insects Across Multiple Spatial ScalesNARA Subscribed
Thermal breadth ( T br ) is a critical trait influencing organisms' response to climate change. Three hypotheses seek to explain interspecific and interpopulation variation in T br , each relying on a different temperature driver: Climate Variability Hypothesis (CVH)–annual temperature range; Thermal Constraints Hypothesis (TCH)–mean annual temperature; and Diel Narrowing Hypothesis (DNH)–mean diel temperature range. We test t...
Submarine landslides can generate tsunamis and pose risks to underwater infrastructure, but a lack of direct observations of such slides hinders our understanding of their development and hazard potential. Studying the morphology of past slides can offer insights into their preconditioning and failure. Here, new high‐quality 2D and 3D seismic data were used to determine, for the first time, the extent and morphology of the Sta...
The key mechanisms associated with the survival of Gulf toadfish, Opsanus beta , when in severe hypoxiaNARA Subscribed
Florida's shallow seagrass beds experience daily diurnal fluctuations in environmental oxygen, leading to hypoxic episodes (PO 2 −1 , ~6 kPa) that have increased in frequency and intensity in recent decades. The native Gulf toadfish ( Opsanus beta ) have been shown to employ a suite of adaptive cardiovascular, ventilatory and metabolic adjustments to survive moderate hypoxia, but little is known of the mechanisms used to survi...
Climate change‐amplified extreme weather events are reshaping ecological communities globally. On coral reefs, heatwaves typically disrupt the obligate coral–algal symbiosis, with symbiont identity a prime determinant of coral resilience to these thermal extremes. Yet, whether heatwaves have long‐term effects on coral symbioses remains unclear due to a lack of longitudinal symbiont data. Here, we report on a decadal coral symb...