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Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve ModelNARA Subscribed
Introduction This study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correlation with the transvalvular pressure. Materials and Methods Porcine (n = 10) and human (n = 4) mitral valves were mounted in a saddle-shaped annulus clamp, while an in vitro system was utilized to replicate a physiological systoli...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Food limitation erodes the thermal tolerance of larvae in an ecologically influential marine herbivoreNARA Subscribed
Biologists often use organismal thermal tolerance to help explain or forecast responses of populations to climate change. Yet many studies quantify thermal tolerance under isolated laboratory conditions despite extreme events, such as heatwaves, often coinciding with other stressors such as nutrient or food limitation. These oversights may be consequential as recent theory suggests thermal tolerance itself can be fundamentally...
In silico & in vitro approaches suggest osteoclastogenesis induction underlying fractures in Entrectinib-treated childrenNARA Subscribed
Entrectinib, a potent, CNS-active, TRK and ROS1 inhibitor is associated with occurrence of bone fractures, particularly in pediatric patients. We embarked on computer-guided and experimental investigations to identify the underlying mechanism that should help safe dosing of children receiving this drug. An artificial intelligence (AI)-based approach was used to allow for hypothesis generation regarding drug effects in a clinic...