Cellular senescence and necroptosis are two cell fates, which trigger an inflammatory response and increase with age, that have been proposed to play a role in inflammaging. In this study, we performed the first study to directly test the possible interaction between necroptosis and cellular senescence. Using a novel Mlkl -KI mouse model, we were able to specifically induce (~ 4-fold) the overexpression of MLKL, the necroptoti...