Maribavir is approved for management of post-transplant cytomegalovirus (CMV) infections refractory and/or resistant to CMV therapies at a dose of 400 mg twice daily (BID). Population pharmacokinetic (PopPK) and exposure–response analyses were conducted to support the appropriateness of 400 mg BID dosing. A PopPK model was developed using non-linear mixed-effects modeling with pooled maribavir plasma concentration–time data fr...

Sea ice thickness (SIT) is a critical and sensitive parameter in the climate system, with its dynamic changes profoundly influencing global climate models, navigational routes, and the potential for Arctic resource development. Given the widespread application of current satellite remote sensing technology in monitoring SIT, significant uncertainties remain. This study first underscores the importance of in-situ observations a...

At present, some shortcomings of the research on coupling modeling of the oceanic front–sound field may need attention: (1) Most of the acoustic propagation simulation is based on ideal front models, but the application of investigated marine data is lacking. (2) Most studies focus on the acoustic field characteristics, with the influence of fronts on acoustic propagation, but few studies aim at the direct quantitative analysi...