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Multi-objective optimization in population pharmacokinetic model selection and optimization: application of NSGA-II in pyDarwinNARA Subscribed
The selection of a “good” model usually involves a combination of objective and subjective criteria. Although many aspects of model quality can be expressed numerically, certain desirable characteristics remain difficult—or even impossible—to quantify precisely. Multi-objective optimization (MOO) provides a systematic way to handle this challenge by explicitly incorporating and balancing both objective (measurable) and subject...
Quantifying the Viscoelastic Properties of Pancreatic Tissue: A Comparative Study of Human, Porcine and Engineered HydrogelNARA Subscribed
Pancreatoduodenectomy (PD) is among the most complex abdominal procedures, with a leak from the pancreatic anastomosis (postoperative pancreatic fistula, POPF) continuing to be a major source of morbidity and mortality. The mechanical characteristics of the pancreas, particularly tissue texture, are closely linked to POPF risk, yet remain poorly defined, limiting the accuracy of currently available training models. This study...
Delta Wing‐Shaped Upper Jaw as a Control Surface to Stabilize Rorqual Whales During Lunge‐FeedingNARA Subscribed
During lunge feeding, rorquals depress their lower jaw to fill the buccal pouch, which can produce a downward pitch on the body from a drag force below the center of mass. It is hypothesized that without flippers the raised upper jaw could produce a counteracting lift to trim the body. Upper jaws of the blue whale and humpback whale have triangular shapes that resemble delta wings. Such wings generate lift without stalling at...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Decomposition of plant litter, facilitated primarily by microbial decomposers, plays a critical role in biogeochemical cycling and ecosystem function. The rate of litter decomposition can determine its environmental impact, where accelerated decomposition alters the timing and rate of nutrient release and may promote nutrient leaching, whereas slowed decomposition can result in litter accumulation, which impacts seedling recru...
Upstate Abundance is a fresh market white-fleshed potato cultivar with resistance to both pathotypes Ro1 and Ro2 of the golden cyst nematode ( Globodera rostochiensis ) as well as to late blight ( Phytophthora infestans ) lineage US-23. It was selected from a cross made at Cornell University in 2000 between the Cornell breeding clone NY121 and the fresh-market cultivar Jacqueline Lee and released by the New York Agricultural E...
Inshore marine coastal zone migration patterns in Atlantic salmon post‐smolts emigrating from eight rivers in north‐east ScotlandNARA Subscribed
Atlantic salmon, Salmo salar , migrate through multiple habitat types, each having the potential to impact differently upon migration success. The inshore marine coastal zone is arguably disproportionately impacted by potential stressors on populations. We investigated the migration of Atlantic salmon post‐smolts ( n = 898) from eight rivers (populations) through the inshore marine coastal zone over a 2‐year period using acous...
Predictions of southern migration timing in coastal sharks under future ocean warmingNARA Subscribed
Projected redistribution of marine species due to ocean warming may undermine current conservation efforts. Yet, there have been few studies on how ocean warming may alter migration timing. Across 5 years of acoustic telemetry data (2018–2022), we determined environmental drivers of southward migration timing for 6 migratory shark species from summer habitats in the Northwest Atlantic Ocean. We then forecasted how migratory ti...
Climate change is a major threat to biodiversity, and migratory animals are particularly vulnerable, due partly to their reliance upon good resource availability across a network of sites at specific times. Migrants perform vital ecosystem functions, transferring significant resources across large spatial scales, but the impacts of climate change on the ability of individuals to complete these journeys are poorly studied. Coll...
Determinants of riverine migration success by Atlantic salmon ( Salmo salar ) smolts from rivers across the UK and IrelandNARA Subscribed
There is some evidence that the river migration success of Atlantic salmon smolts, on their first migration to sea, varies both spatially and temporally. However, we have only a poor understanding of what may be driving this variation. In this study, we used acoustic telemetry to quantify the spatial and temporal variations in river migration success in Atlantic salmon smolts on their first migration to sea. In total 4120 Atla...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...