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P-glycoprotein (P-gp) is an ATP-dependent efflux transporter that contributes to cellular defense by exporting xenobiotics. While well characterized in mammals, its inducibility and physiological regulation in fish remain poorly understood. This study examined the functional induction of P-gp in juvenile rainbow trout (Oncorhynchus mykiss) hepatocytes following xenobiotic exposure and assessed how energy status (fed vs. fasted...
Optimising Instrumented Mouthguard Data Analysis: Video Synchronisation Using a Cross-correlation ApproachNARA Subscribed
Purpose Head acceleration events (HAEs) are a growing concern in contact sports, prompting two rugby governing bodies to mandate instrumented mouthguards (iMGs). This has resulted in an influx of data imposing financial and time constraints. This study presents two computational methods that leverage a dataset of video-coded match events: cross-correlation synchronisation aligns iMG data to a video recording, by providing play...
Recommendations for Method Development and Validation of qPCR and dPCR Assays in Support of Cell and Gene Therapy Drug DevelopmentNARA Subscribed
The emerging use of qPCR and dPCR in regulated bioanalysis and absence of regulatory guidance on assay validations for these platforms has resulted in discussions on lack of harmonization on assay design and appropriate acceptance criteria for these assays. Both qPCR and dPCR are extensively used to answer bioanalytical questions for novel modalities such as cell and gene therapies. Following cross-industry conversations on th...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Freshwater early life growth influences partial migration in populations of Dolly Varden (Salvelinus malma malma)NARA Subscribed
Populations of northern Dolly Varden ( Salvelinus malma malma ) exhibit partial seaward migration, yet little is known about this phenomenon in Dolly Varden populations. Our study analyzed data from three different Dolly Varden populations in the western Canadian Arctic in order to determine if: (1) differences in size-at-first seaward migration exist between fish that migrate at early and late ages among populations inhabitin...
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